阿普斯特一次能囤几盒?多少钱?

Apremilast regulates the production of inflammatory mediators by inhibiting the activity of PDE4, thereby reducing the inflammatory response. Its indications include moderate to severe plaque psoriasis, psoriatic arthritis and oral ulcers related to Behcet's disease. The quantity and price of its medicines are the focus of patients' attention. This article will provide patients with a comprehensive medication reference from three aspects: reasonable medication stocking suggestions, market price analysis, and medication guidance for special groups.

How many boxes of Apremilast can be stocked at a time?

The number of medicines to be stocked must take into account factors such as treatment effect, drug validity period, and personal medication needs.

Calculation of treatment cycles

The standard treatment plan is 30 mg twice a day. According to this calculation, the 30-capsule pack can be used for 15 days, and the 60-capsule pack can be used for 30 days. It is recommended to prepare 2-3 months’ supply, about 4-6 boxes of 30 capsules or 2-3 boxes of 60 capsules.

Drug Validity Period

Apremilast is usually valid for 24-36 months. When stocking up, you need to check the production date to ensure that it is used within the validity period. Avoid hoarding too much at once and causing medicines to expire.

Customs restrictions

When purchasing cross-border medicines, you must abide by the quantity limit for personal use. Usually, a single mailing does not exceed 3 months' supply. It is recommended to purchase in installments to avoid customs inspection problems.

Patients should consult their attending physician before stocking up on medicines to determine the most appropriate purchase quantity based on the severity of their condition and review plan.

How much does Apremilast cost?

The market price of Apremilast varies significantly depending on specifications, brands and purchase channels.

Original drug price

The price of the original drug Otezla is relatively high, with a 30mg × 60 capsule size of approximately US$4,700 in the US market.

Prices of generic drugs in India

Apremilast produced by Glenmark Pharmaceuticals in India is available in two specifications. The price of 30mg×30 tablets is about US$22 per box, and the price of 30mg×60 tablets is about US$32 per box.

Bulk purchase discounts

You can usually enjoy a partial discount if you purchase 3 or more boxes, and some channels offer a 6-box set discount.

Patients are advised to compare prices and services from different channels, choose regular and reliable suppliers, and keep complete proof of purchase.

Apremilast medication for special groups

Patients with different physiological conditions should pay special attention to dose adjustment and risk prevention when using Apremilast.

Pediatric Medication

It can be used by children aged 6 years and above. The dosage needs to be adjusted according to body weight. The safety and effectiveness in children under 6 years old have not been established yet.

Geriatric use

Patients over 65 years old do not need to adjust the dosage, but they need to be closely monitored for adverse reactions, especially weight loss and gastrointestinal symptoms.

Hepatic and renal insufficiency

For patients with mild to moderate hepatic insufficiency, it is recommended to start with 20 mg once a day and gradually increase to a tolerated dose. It is contraindicated in patients with severe hepatic insufficiency, and no dose adjustment is required in patients with renal insufficiency.

Pregnant women and lactating women

Contraindicated for pregnant women as it may cause harm to the fetus. Women of childbearing age need to take reliable contraceptive measures during medication. Not recommended for use during lactation.

Depressed patients

Those with a history of depression should use it with caution. During treatment, emotional changes should be closely monitored. If depression worsens, timely medical attention is required.

Special groups should fully communicate with their doctors before using Apremilast to develop an individualized medication plan and monitoring plan.