阿普斯特可以治疗神经性皮炎与红斑狼疮吗？

Apremilast is mainly used to treat psoriasis, psoriatic arthritis, etc. It can also be used to treat neurodermatitis and lupus erythematosus. Patients with neurodermatitis and lupus erythematosus can receive standardized treatment under the guidance of a doctor.

Treat neurodermatitis

Neurodermatitis is generally related to genetics, immunity, environmental factors, mental factors, endocrine disorders, gastrointestinal dysfunction, stimulation, diet and other factors. It is a relatively common clinical skin disease. Apremilast can relieve symptoms such as itching in patients with neurodermatitis, prevent skin lesions from being further stimulated by scratching, and cut off the vicious cycle of "itching-scratching-itching".

Apremilast is an orally administered small molecule drug that specifically inhibits the enzyme phosphodiesterase-4 and modulates the immune system by increasing intracellular cyclic adenosine monophosphate (cAMP) levels and inhibiting the production of IL-2 and 8, interferon-γ, and tumor necrosis factor (TNF). FDA approved for the treatment of psoriasis, psoriatic arthritis, and Behcet's disease oral ulcers. In addition, Apremilast is used off-label for various skin conditions in which systemic corticosteroids or immunosuppressive agents are ineffective.

Research has found that Apalstein can inhibit PDE-4 activity, thereby improving the inflammatory response. It can also reduce the production of prostaglandin E2, block the activation and evolution of Th1, Th2, Th17 and other immune cells, and reduce the release of inflammatory factors, thus.

Apremilast treats lupus erythematosus

Lupus erythematosus (LE) is a chronic, recurrent autoimmune disease caused by autoimmune abnormalities, which can manifest as butterfly-shaped erythema, fever, joint discomfort, headache, mental disorder, pale complexion and other symptoms. Apremilast can mediate the increase of immunoregulatory cAMP in immune cells by inhibiting the cAMP-degrading enzyme PDE4, which can inhibit the inflammatory response, thereby improving clinical symptoms and relieving uncomfortable symptoms such as joint pain and erythema in patients with lupus erythematosus.

Patients with lupus erythematosus and neurodermatitis should avoid spicy and irritating foods. People with allergies should avoid eating allergenic foods such as fish, shrimps, crabs, nuts, etc. During the medication process, attention should be paid to adverse reactions and avoid using photosensitive drugs. Pay attention to sun protection when going out to avoid trauma. After a period of recovery, you should check regularly to understand changes in the condition.

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