阿普斯特OTEZLA治疗银屑病效果如何？治疗时要注意什么

Psoriasis is a severe, chronic inflammatory disease that causes raised, red scales on the skin, usually affecting the elbows, knees, or the outside of the scalp, but can appear anywhere. Apremilast OTEZLA is an oral, selective small molecule inhibitor of phosphodiesterase 4 (PDE4) that can be used to treat: adult patients with moderate to severe plaque psoriasis, adult patients with active psoriatic arthritis, and adult patients with oral ulcers associated with Behcet's disease. How effective is it in treating psoriasis? What should I pay attention to during treatment?

Apremilast OTEZLA treatment effect

The Phase 3 DISCREET study (PSOR-025) evaluated the oral anti-inflammatory drug Apremilast OTEZLA in adults with moderate to severe genital psoriasis.

The results showed that at week 16 of treatment, a significantly higher proportion of patients in the Apremilast OTEZLA treatment group achieved an sPGA-G response compared with the placebo group. Compared with the placebo group, the Apremilast OTEZLA treatment group had significant improvements in Genital Psoriasis Numerical Rating Scale (GPI-NRS) response, change from baseline in affected body surface area (BSA), change from baseline in Dermatology Life Quality Index (DLQI), and sPGA response. Apremilast OTEZLA can significantly improve the patient's condition, reduce the patient's pain, improve the patient's quality of life, have a positive effect on the patient's condition, and has a significant therapeutic effect.

Apremilast OTEZLA Precautions

Treatment with Apremilast OTEZLA may cause depression. During treatment, patients should pay attention to the emergence and worsening of depression. If suicidal thoughts or other emotional changes occur, they should communicate with their doctor in time, and the doctor will adjust the medication plan. Patients should not blindly use other drugs for treatment.

Treatment with Apremilast OTEZLA may result in weight loss, and patients should monitor their weight regularly while on treatment. If unexplained or clinically significant weight loss occurs, seek medical attention promptly. Depending on its severity, patients may need to consider discontinuing treatment with Apremilast.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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