阿普斯特怎么服用？阿普斯特有什么禁忌和注意事项？

Apremilast is indicated for the treatment of adults with active psoriatic arthritis and for the treatment of patients with psoriasis. Apremilast is a first-in-class oral, selective phosphodiesterase-4 (PDE-4) inhibitor and the first oral drug approved for psoriatic arthritis in the past 15 years. It works differently than other types of oral systemic medications used to treat psoriasis, affecting the entire immune system.

How to take Apremilast?

To reduce the risk of gastrointestinal symptoms, titrate Apremilast to the recommended dose of 30 mg twice daily according to schedule. The first day: 10 mg in the morning; the second day: 10 mg in the morning, 10 mg in the evening; the third day: 10 mg in the morning, 20 mg in the evening; for more details, please refer to the medication instructions. In cases of severe renal impairment, the recommended dose is 30 mg once daily. For initial dose titration, use only the morning schedule for titration and skip the afternoon dose. If you need to take Apremilast, it is recommended that you consult your doctor before using Apremilast and avoid taking it without knowledge.

What are the taboos and precautions for Apremilast?

Apremilast can be taken with or without food, but the tablets must not be crushed, split, or chewed. During treatment, attention should be paid to this product. Patients known to be allergic to the prodrugs or any excipients in the preparation are prohibited from taking this product. Patients must follow the doctor's instructions and do not change the dosage and usage at will to avoid intolerance reactions. Advise patients, their caregivers, and families to be aware of the emergence or worsening of depression, suicidal thoughts, or other mood changes. There have been postmarketing reports of severe diarrhea, nausea, and vomiting associated with the use of apremilast.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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