银屑病吃了甲氨蝶呤没效果怎么办？甲氨蝶呤效果好吗？

Methotrexate tablets mainly act on the S phase of the cell cycle and are cell cycle-specific drugs. They also have a delaying effect on cells in the G1/S phase, but have a weak effect on cells in the G1 phase. The time for the effectiveness of methotrexate tablets varies from person to person. The time for the effectiveness of the tablets is related to various factors such as the user's condition and the absorption and utilization of the drug. Today we will learn about psoriasis, what to do if methotrexate is not effective? Is methotrexate effective?

Methotrexate is effective in treating psoriasis. Methotrexate is hepatotoxic, but it is still commonly used to treat psoriasis in Europe and the United States because of its rapid onset, economy, safety, reliability, ease of use, and accurate efficacy.

In clinical studies, 40 patients with psoriasis were treated with oral methotrexate. There was no need to stop taking the medication if the above adverse reactions occurred. Appropriate adjustment of the dose can eliminate and reduce the adverse reactions. Therefore, methotrexate is safe and effective in treating psoriasis and is worthy of clinical use.

As a folate reductase inhibitor, methotrexate tablets mainly inhibit dihydrofolate reductase and prevent dihydrofolate from being reduced to physiologically active tetrahydrofolate, thereby blocking the transfer of one-carbon groups during the biosynthesis of purine nucleotides and pyrimidine nucleotides, resulting in the inhibition of DNA biosynthesis.

In 1971, the US FDA approved methotrexate for the treatment of severe psoriasis. Its mechanism of action may be to achieve the purpose of treating psoriasis by inhibiting the synthesis of DNA and RNA in keratinocytes, inhibiting the production of growth factors in patients' vascular endothelial cells, and inhibiting the proliferation of lymphocytes.

Methotrexate tablets are multi-targeted drugs approved to treat various types of acute leukemia, malignant lymphoma, non-Hodgkin's lymphoma and mycosis fungoides, multiple myelopathy, ovarian cancer, cervical cancer, head and neck cancer, lung cancer, various soft tissue sarcomas, psoriasis, breast cancer, malignant mole, chorioepithelial carcinoma, testicular cancer, etc.

Methotrexate tablets Trexall is a light orange-yellow tablet drug that is administered orally. Because it has immunosuppressive and anti-inflammatory effects, methotrexate tablets Trexall can also be used for autoimmune diseases. The dosage is small and the safety is relatively high. Most patients can tolerate it. However, Trexall, a methotrexate tablet, is a prescription drug and patients must start using it under the guidance of a professional doctor.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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