氯法齐明软胶囊的作用和疗效？

Multidrug-resistant tuberculosis (MDR-TB) has always been the focus and difficulty of tuberculosis prevention and treatment.耐药结核病的治疗疗程长、治愈

The rate is low and the failure rate is high. Multidrug-resistant tuberculosis has become a major public health problem. The therapeutic activity of clofazimine is similar to that of rifampicin, isoniazid and other anti-tuberculosis drugs. Most drug-resistant tuberculosis bacteria are sensitive to it. It not only has anti-Mycobacterium leprae effect, but is also effective against MDR-TB when combined with other anti-mycobacterial drugs, which can improve the effectiveness of treatment. So, what is the role and efficacy of clofazimine soft capsules?

氯法齐明软胶囊的作用

Clofazimine is mostly used to treat infections caused by leprosy and mycobacterial complex. Its mechanism of action is mainly by interfering with bacterial nucleic acid metabolism, binding to its DNA, inhibiting RNA polymerase, blocking RNA synthesis, inhibiting bacterial protein synthesis, and playing an antibacterial effect.

氯法齐明软胶囊的疗效

Research purpose: To observe the effectiveness of clofazimine combined with conventional anti-tuberculosis drugs in the treatment of multi-drug-resistant pulmonary tuberculosis [1].

Research methods: A total of 80 patients diagnosed with multi-drug-resistant tuberculosis through drug sensitivity tests were randomly divided into two groups. The control group was treated with conventional anti-tuberculosis drugs, while the observation group was treated with clofazimine in addition to conventional drugs. Statistically compare clinical data such as phlegm negative conversion rate, treatment effects and adverse reactions.

Research results: After 3 months of treatment, the sputum negative conversion rates of the observation group and the control group were 32.50% and 12.50% respectively, with significant differences (P<0.05). After 6 months of treatment, the effective rates of treatment in the observation group and the control group were 72.50% and 32.50%, with significant differences (P<0.05). In terms of adverse reactions, only the observation group had skin discoloration, and there was no significant difference in other adverse reactions (P>0.05).

Research conclusion: Clofazimine combined with conventional anti-tuberculosis drugs is safe and worthy of promotion for the treatment of multi-drug-resistant pulmonary tuberculosis.

References

[1] Li Hao, Wang Yuncai, Zheng Yibin, et al. Clinical efficacy of clofazimine combined with conventional anti-tuberculosis drugs in the treatment of multi-drug-resistant pulmonary tuberculosis [J]. Chinese Journal of Emergency Resuscitation and Disaster Medicine, 2021, 16(09): 1033-1035.

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