氯法齐明和环丝氨酸哪个好？

With the development of the molecular biology of drug-resistant tuberculosis, the rapid detection of rifampicin-resistant genes provides the possibility for early diagnosis of drug-resistant tuberculosis. Therefore, in 2016, the WHO divided tuberculosis drugs into ABCD4 groups based on the strength of their effects: Group A is fluoroquinolone Group B is an injectable anti-tuberculosis drug; Group C is the core drug, including the original prothionamide, cycloserine and para-aminosalicylic acid. Currently, linezolid and cycloserine are newly added. So in Group C, which drug is better, clofazimine or cycloserine?

cycloserine

Cycloserine was successfully developed in the 1950s, more than 60 years ago. Cycloserine has good antibacterial activity against Mycobacterium tuberculosis and was once the main anti-tuberculosis drug. However, with the successful development of more effective drugs such as rifampicin, and cycloserine has mental and neurological adverse reactions, it has been gradually eliminated clinically. With the increase in drug-resistant tuberculosis patients, cycloserine has received renewed attention due to its low drug resistance. In the 2008 emergency revised version of the "Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis", WHO listed cycloserine as a Group 3 drug, that is, an oral bacteriostatic second-line anti-tuberculosis drug.

clofazimine

Clofazimine is an anti-mycobacterial drug developed in the 1940s. It is mainly used for the treatment of leprosy. However, with the emergence of drug-resistant tuberculosis, this drug has also been included in the treatment of drug-resistant tuberculosis. The most effective treatment plan is the standardized regimen containing clofazimine for 9 to 12 months in Bangladesh. 206 patients achieved a sputum negative conversion rate of 87.9% without recurrence, and 515 patients achieved a sputum negative conversion rate of 84.4%.

Which drug is better, clofazimine or cycloserine?

Can't decide which one is better, clofazimine or cycloserine. Clinically, there is no real distinction between good and bad medicines, but it is important to prescribe the right medicine. The final medicine used should be decided by the doctor based on your test results, and should not be decided by yourself.

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