氯法齐明功能主治和疗效

Clofazimine is a drug used to treat multi-drug-resistant tuberculosis. It can inhibit Mycobacterium leprae and Mycobacterium avium. It has similar pharmacological activities to anti-tuberculosis drugs such as isoniazid and rifampin, and is fully sensitive in multi-drug-resistant tuberculosis. A large number of scholars have found that the excellent anti-multi-drug-resistant tuberculosis effect is more obvious in vitro, and the clinical effect on multi-drug-resistant tuberculosis is more ideal when used in combination with other conventional anti-tuberculosis drugs. After 12 months of treatment, the sputum negative rate of patients can reach 85%.

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80 patients with multidrug-resistant tuberculosis were selected as the research subjects, and the patients were divided into two groups using the odd and even number method. The control group: conventional combined treatment, and the experimental group: conventional tuberculosis treatment + clofazimine. Compare the lesion absorption rate after treatment and the changes in sputum bacteria 6 months and 18 months after treatment between the two groups of patients. Results The absorption rate of the test group (85%) and the control group (65%). The absorption rate of the test group was significantly higher than that of the control group, and there was a significant difference with statistical significance (P<0.05). Six months after treatment, the negative conversion rate was 65% in the test group and 45% in the control group. There was no significant difference in the changes in sputum bacteria between the two groups after 6 months of treatment, and there was no statistical significance (P>0.05). The negative conversion rate of the test group (80%) and the control group (50%) 18 months after treatment was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).

It is concluded that in the application of clofazimine combination regimen in the treatment of multi-drug-resistant tuberculosis, the intensive treatment period can significantly increase the negative conversion rate and at the same time increase the lesion absorption rate, which has important clinical value.

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