氯法齐明的作用和功效分别是什么？

Clofazimine was launched as a leprosy treatment drug in 1969 by the Swiss company Ciba Geigy, and in 1986, clofazimine was approved by the US FDA. At this stage, clofazimine is mainly used as the drug of choice for the treatment of neoplastic leprosy, especially for the treatment of infections caused by strains resistant to sulfone drugs. Clofazimine is a drug used to treat neoplastic leprosy. Used in combination with dapoxone, it can consolidate the efficacy of clofazimine and can also be used to treat erythematous nodular leprosy. What are the functions and effects of clofazimine?

The effects of clofazimine

Clofazimine is a commonly used capsule, which contains brown-red or reddish-brown suspension oily liquid. The main component is clofazimine. Clofazimine can be used for the treatment of leprosy and can also be used as the first-choice treatment drug. If necessary, it can be used in combination with other drugs, such as rifampicin or ethionicotinamide. It can effectively treat sulfone-resistant bacterial infections. Clofazimine has a significant effect.

Clofazimine has multiple anti-MTB action mechanisms. Its most likely action mechanism is by interfering with the nucleic acid metabolism of Mycobacterium tuberculosis MTB, binding to its DNA, inhibiting deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase, preventing RNA synthesis, thereby inhibiting bacterial protein synthesis and exerting its antibacterial effect.

Clofazimine efficacy

Clofazimine is the drug of choice for the treatment of neoplastic leprosy. It is also used clinically for patients who are intolerant to sulfone drugs. In addition, clofazimine also has certain effects on chronic discoid lupus erythematosus, skin ulcers, and pyoderma gangrenosum. Clofazimine has positive effects on leprosy, and is also very effective on patients with tumors that are resistant to sulfone drugs. It is manifested in the reduction of skin lesions and the significant decrease in bacterial morphological index. Clofazimine has both preventive and therapeutic effects on leprosy erythema nodosum. The incidence and severity of leprosy erythema nodosum in tumor-type patients treated with clofazimine are significantly lower than those treated with DDS. For long-term glucocorticoid-dependent erythema nodosum leprosy, glucocorticoids can be gradually withdrawn after treatment with clofazimine. In addition, clofazimine is also effective in treating neuritis caused by type I leprosy.

The above is an introduction to clofazimine. If patients have other questions about the drug (such as drug prices, purchase channels, etc.), they can consult the medical companion travel service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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