日本埃索美拉唑是胃药吗

Is Japanese esomeprazole a stomach medicine?

Esomeprazole is indicated for gastroesophageal reflux disease (GERD) - treatment of erosive reflux esophagitis - long-term maintenance treatment to prevent recurrence in patients with cured esophagitis - symptom control of gastroesophageal reflux disease (GERD) - eradication of Helicobacter pylori in combination with appropriate antimicrobial therapy and healing of duodenal ulcers associated with Helicobacter pylori infection - prevention of recurrence of peptic ulcers associated with Helicobacter pylori infection.

Esomeprazole is a weak base, which is concentrated in the high-acid environment of the acid secretion microtubules of parietal cells and converted into an active form, thereby inhibiting the H+/K+-ATPase (proton pump) at this site, inhibiting both basic gastric acid secretion and stimulated gastric acid secretion. Esomeprazole should be taken and discontinued correctly according to the condition and under the guidance of a professional doctor to ensure medication safety.

Esomeprazole tablets should be swallowed whole with liquid and should not be chewed or crushed. Gastroesophageal reflux disease (GERD) - treatment of erosive reflux esophagitis, 40 mg once daily for four weeks. For patients whose esophagitis has not been cured or who have persistent symptoms, it is recommended to take medication for another four weeks. - Long-term maintenance treatment for cured esophagitis patients to prevent recurrence, 20 mg once daily.

Effects of Esomeprazole on the Pharmacokinetics of Other Drugs For those drugs whose absorption is affected by gastric acid, the absorption of these drugs may be increased or decreased during esomeprazole treatment due to a decrease in gastric acidity. As with other oxyntoinhibitors or antacids, the absorption of ketozole and itraconazole will be reduced during esomeprazole treatment.

Esomeprazole is metabolized by CYP 2C19 and CYP 3A4. Coadministration of esomeprazole with the CYP 3A4 inhibitor clarithromycin (500 mg twice daily) can double the area under the plasma concentration-time curve (AUC) of esomeprazole, but the dose of esomeprazole does not need to be adjusted.