阿瑞匹坦有几种规格?多少钱?

Aprepitant is mainly used to prevent acute and delayed nausea and vomiting associated with initial or repeated courses of highly emetogenic chemotherapy (HEC, such as high-dose cisplatin) and moderately emetogenic chemotherapy (MEC). This article will introduce in detail the different specifications, prices and precautions of aprepitant when using it.

Aprepitant comes in several strengths

Capsule dosage forms

The most common dosage form of aprepitant is capsule, which contains two main strengths: 80mg and 125mg. These two specifications are used at different stages of treatment to meet the needs of different patients.

Suspension dosage form specifications

For children or certain adult patients who are unable to swallow capsules, aprepitant is also available in a suspension dosage form. Each sachet of suspension contains 125mg of active ingredient, allowing easy dosage adjustment and ensuring accurate dosing.

Injection dosage form specifications

Although it has not been widely popularized in China, aprepitant is also available in injection dosage form. This dosage form is especially suitable for patients who are not suitable for oral medication. The specification is submicroemulsion injection, which is convenient for clinical application.

How much does Aprepitant cost in different specifications?

Indian Greenmark Pharmaceutical Factory Edition

The specifications of Aprepitant capsules produced by Greenmark Pharmaceutical Factory in India are 125mg*1 capsule + 80mg*2 capsules, and the price per box is about US$9. The price is relatively affordable and suitable for patients who need to take it for a long time.

Domestic generic version

In the domestic market, the first generic capsule "Oukeping" launched by Qilu Pharmaceutical and products from other manufacturers such as Zhengda Tianqing Pharmaceutical and Nanjing Entai Pharmaceutical have gradually entered the market. Due to competition from domestic generic drugs, the price has dropped compared to the original drug, but the specific price depends on local medical insurance policies and personal circumstances.

Price of injection dosage forms

Although the aprepitant injection developed by Heron Therapeutics has been approved abroad, it has not been widely used in China. Injections are relatively expensive and are mainly used for patients who are not suitable for oral medications.

Precautions for aprepitant

CYP3A4 interaction

Aprepitant is a CYP3A4 substrate and a weak to moderate inhibitor and may increase the plasma concentration of drugs metabolized by this enzyme. Therefore, special attention should be paid to monitoring and dose adjustment when used in combination with other drugs such as benzodiazepines and dexamethasone.

Effects of Warfarin

Patients taking warfarin (a CYP2C9 substrate) may experience a decrease in INR values ​​while taking aprepitant. It is recommended to closely monitor coagulation function for 7-10 days after administration.

Use of hormonal contraceptives

Aprepitant may reduce the effectiveness of hormonal contraceptives, so non-hormonal contraceptive methods, such as condoms, should be used during use of aprepitant until 28 days after the last dose.