阿瑞匹坦有哪几个版本?分别多少钱?

Aprepitant can be used in combination with other antiemetics to prevent acute and delayed nausea and vomiting associated with initial or repeated courses of highly emetogenic chemotherapy (HEC, such as high-dose cisplatin) and moderately emetogenic chemotherapy (MEC) in patients aged ≥12 years. This article will take an in-depth look at the different versions of aprepitant, their prices, and their effectiveness.

What are the versions of aprepitant?

Capsule form

The most common form of aprepitant is the capsule form, which was developed by Merck & Co. of the United States and was approved for marketing in the United States in 2003. This dosage form is usually used for the prevention of acute and delayed nausea and vomiting caused by chemotherapy in adults and adolescents over 12 years old.

Suspension dosage form

In addition to capsule dosage form, aprepitant also has a suspension dosage form, which is suitable for children from 6 months to 12 years old or those who are unable to swallow capsules. This dosage form makes it easy to adjust the dosage to meet the needs of patients of different ages.

Injection dosage form

Although the aprepitant injection dosage form developed by Heron Therapeutics has not yet been launched in China, it has been approved by the FDA abroad for use in patients who are not suitable for oral medications.

How much do different versions of Aprepitant cost?

Indian Greenmark Pharmaceutical Factory Version

The specifications of Aprepitant capsules produced by Greenmark Pharmaceutical Factory in India are 125mg 1 capsule + 80mg 2 capsules, and the price per box is about US$9. The price is relatively affordable and is a good choice for patients who need to use aprepitant for a long time.

Domestic generic version

The first generic capsule "Oukeping" launched by Qilu Pharmaceutical, as well as products from Chia Tai Tianqing Pharmaceutical, Nanjing Entai Pharmaceutical and other companies, are also available in the Chinese market. Due to competition from domestic generic drugs, the price has dropped compared to the original drug, but the specific price depends on local medical insurance policies and personal circumstances.

Injection dosage forms

Although injection dosage forms are already on the market abroad, due to their high price and not being widely popularized in China, they are currently mainly used by patients who cannot take oral medications, and the cost is relatively high.

Efficacy of aprepitant

Combination effect

Aprepitant is often used in combination with other antiemetics such as dexamethasone and 5-HT3 receptor antagonists to enhance the control effect on nausea and vomiting associated with highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC).

Effects on specific populations

Studies have shown that aprepitant is very effective in preventing nausea and vomiting associated with chemotherapy for the first or repeated courses in adults and adolescents aged ≥12 years. At the same time, the application of suspension dosage forms in children has also shown good tolerability and effectiveness.

Although aprepitant has significant efficacy, it may also cause some adverse reactions, such as fatigue, diarrhea, headache, etc. Therefore, patient response should be closely monitored during use and treatment regimens should be adjusted on a case-by-case basis.