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On October 10, 2014, the US FDA approved palonosetron hydrochloride capsules for the treatment of nausea and vomiting caused by chemotherapy in cancer patients.

Palonosetron hydrochloride capsule is a compound capsule composed of two drugs. Palonosetron is a 5-HT3 receptor antagonist, which is mainly used for acute nausea and vomiting symptoms that occur within 24 hours after the start of cancer chemotherapy. Netupitant is a new drug that is suitable for nausea and vomiting symptoms that occur in the acute phase (within 24 hours) and delayed phase after the start of cancer chemotherapy.

Palonosetron Hydrochloride Capsules

For nausea and vomiting caused by chemotherapy, the recommended dose for adults is to take a single oral dose of this product about 1 hour before chemotherapy, with or without food.

taboo groups

1. Patients who are allergic to palonosetron hydrochloride or similar drugs may experience hypersensitivity reactions after taking the drug, which may endanger their health.

2. Have serious heart disease, such as angina pectoris, cardiac insufficiency, etc.

3. Patients with severe liver function damage and kidney damage. Avoid use in patients with severe hepatic impairment and avoid use in patients with severe renal impairment or end-stage renal disease.

In addition, for patients under 18 years of age. The safety and effectiveness of palonosetron hydrochloride in this age group has not been established, so use of this drug in minors is not recommended.

Palonosetron hydrochloride capsules

Palonosetron, available in oral and intravenous (IV) formulations, is a fixed-dose combination of the neurokinin 1 (NK1) receptor antagonist netupitant (or the prodrug fosnetupitant in IV formulations) and the second-generation serotonin 3 (5-HT3) receptor antagonist palonosetron.

Palonosetron hydrochloride capsules (in combination with dexamethasone) are administered as a single dose for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in adults. In clinical trials, palonosetron hydrochloride capsules plus dexamethasone were associated with high rates of complete remission (no vomiting and no rescue medications) in the acute, delayed and overall phases in patients receiving highly or moderately emetic chemotherapy, with efficacy maintained across multiple cycles.

In addition, in individual trials, oral palonosetron hydrochloride capsules were found to be superior to palonosetron and non-inferior to aprepitant plus granisetron in preventing CINV. Both oral and intravenous formulations of the drug combination were well tolerated. The fixed-dose combination is consistent with guideline recommendations and provides a simple and convenient option for the prevention of acute and delayed CINV in patients receiving highly or moderately emetogenic chemotherapy.

Precautions for Palonosetron Hydrochloride Capsules

1. Consult a doctor before taking medication: Before starting to use Palonosetron Hydrochloride Capsules, you should consult a doctor and inform the doctor in detail about your medical history, allergies, other drugs you are taking, and existing health conditions.

2. Follow the doctor's instructions: Please use Palonosetron Hydrochloride Capsules correctly according to the doctor's prescription and usage instructions, and do not change the dosage or stop using it at will.

3. Pay attention to possible adverse reactions: Palonosetron hydrochloride capsules may cause some adverse reactions, such as headache, fatigue, nausea, vomiting, diarrhea, arrhythmia, etc. If you experience any discomfort, please inform your doctor immediately.

4. Pay attention to interactions with other drugs: Palonosetron Hydrochloride Capsules may interact with other drugs, including over-the-counter drugs, supplements, and herbal products. Before using palonosetron hydrochloride capsules, inform your doctor of all medications you are taking to avoid potential adverse reactions.

5. Pregnant and lactating women should use it with caution: Palonosetron hydrochloride capsules may have certain effects on the embryo and fetus. Pregnant and lactating women should use it under the guidance of a doctor and inform the doctor of the relevant situation.

6. Pay attention to storage: Palonosetron hydrochloride capsules should be stored in a cool, dry place, away from direct sunlight and moisture.

Summary

The above explains the usage, dosage, precautions, etc. of Palonosetron Hydrochloride Capsules. It is recommended that patients consult a professional doctor before using any medicine, strictly follow the doctor's instructions, and do not self-medicate or stop using medicine to avoid adverse effects on health.

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