帕洛诺司琼注射液和胶囊的用量一样吗？

The dosage of palonosetron injection and capsules is different. For example, the recommended dosage of palonosetron injection for preventing nausea and vomiting caused by chemotherapy is 0.25 mg. The dosage of palonosetron hydrochloride capsule is 0.5 mg, which is one capsule. Patients need to choose the appropriate dosage form according to their condition under the guidance of a doctor and clarify the dosage.

Palonosetron indications

The second-generation serotonin 5-HT3 receptor antagonist has a stronger affinity. Chemotherapy drugs stimulate intestinal chromaffin cells to release 5-HT. 5-HT reactivates the 5-HT3 receptor on the vagus afferent nerve, thereby causing the vomiting reflex. The 5-HT3 receptor can selectively participate in the vomiting reaction.

Palonosetron can prevent nausea and vomiting in the acute phase caused by highly emetogenic chemotherapy, and nausea and vomiting in the acute and delayed phases caused by moderately emetogenic chemotherapy. The injection can also prevent post-operative nausea and vomiting within 24 hours after surgery.

Palonosetron injection and capsules

1. Palonosetron Hydrochloride Injection: When used to prevent nausea and vomiting caused by chemotherapy, the recommended dose is 0.25 mg. It needs to be injected intravenously about 30 minutes before chemotherapy, and the injection time should be more than 30 seconds. When used to prevent nausea and vomiting after surgery, the recommended dose is 0.075mg, which needs to be injected intravenously as a single dose immediately before induction of anesthesia. The injection time should be more than 10 seconds.

2. Palonosetron Hydrochloride Capsules: You need to take 0.5mg of this product orally about 1 hour before chemotherapy.

Palonosetron's

1. Gastrointestinal system diseases: such as diarrhea, constipation, indigestion, abdominal pain, dry mouth, hiccups, and flatulence.

2. Nervous system diseases: such as dizziness, drowsiness, insomnia, emotional hyperactivity, and abnormal sensation.

3. Cardiovascular system diseases: Rarely, intermittent tachycardia, bradycardia, sinus tachycardia, sinus arrhythmia, QT interval prolongation, hypotension, hypertension, myocardial ischemia, and extrasystole.

4. Metabolic system diseases: such as hyperkalemia, electrolyte imbalance, hyperglycemia, loss of appetite and anorexia, metabolic acidosis, etc.

5. Systemic symptoms: such as weakness, fatigue, fever, hot flashes and flu-like symptoms.

6. Allergic reactions: including swelling, erythema, itching, rash, urticaria, difficulty breathing, and bronchospasm.

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