化疗止吐新药阿瑞匹坦的功效及副作用是什么？

When patients receive clinical chemotherapy treatment, they must successfully complete 4 or 6 courses of chemotherapy in order to effectively ensure the treatment effect and achieve the purpose of prolonging survival. Therefore, during the treatment process, appropriate measures need to be taken to reduce the patient's vomiting reaction. Relevant surveys have shown that the factors causing vomiting in patients with acute vomiting and delayed vomiting are different. Among them, 5-HT3 is the main factor causing acute vomiting in patients, and substance P is a secondary cause. The main cause of delayed vomiting is substance P and the secondary cause is 5-HT3. Therefore, in the process of antiemetics, it is also necessary to inhibit their release through appropriate drugs from the perspective of 5-HT3 and substance P. This is the appropriate drug. What are the efficacy and side effects of the new chemotherapy antiemetic drug aprepitant?

Aprepitant is a neurokinin-1 receptor blocker with high selectivity and affinity. When this drug is used for antiemetics, it blocks substance P by binding to the receptor NK-1. Relevant studies have shown that this drug can have a strong antiemetic effect on multiple tumor types such as the lung, gastrointestinal, reproductive system, etc.

Symptoms include: tachycardia, weakness, hiccups, weakness/tiredness, hypokalemia, anxiety, redness, upper respiratory tract infection, elevated liver index ALT, pain, rash, bradycardia, disorientation, constipation, pelvic pain, bone pain, headache, anorexia, perforated duodenal ulcer, Stevens-Johnson syndrome, etc. If you are currently using aprepitant, the editor here recommends that patients must take the medication correctly according to the doctor's instructions. Some patients always think that simply increasing the dose of the drug can improve the effect of the drug itself, and they also think that simply reducing the dose of the drug can reduce the occurrence of side effects. However, this is not actually the case. If the dose of the drug is changed privately, it may cause more adverse reactions, so do not use the drug blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.