用阿瑞匹坦治疗时的相关不良反应

Aprepitant is a gray-white to light yellow crystal-like solid chemical, also known as Yimei. It is suitable for preventing acute and delayed nausea and vomiting during the initial and repeated treatment of highly emetogenic anti-tumor chemotherapy. It is administered in combination with other antiemetic drugs. But drugs usually have adverse reactions. Today we will take a look at the related adverse reactions when treated with aprepitant.

The most common adverse reactions of aprepitant include: increased liver index ALT, hiccups, weakness/tiredness, constipation, headache, and anorexia. Other adverse reactions of Aprepitant include: bone pain, rash, redness, pelvic pain, upper respiratory tract infection, tachycardia, hypokalemia, anxiety, etc. Patients have also been reported to have perforated duodenal ulcers, bradycardia, disorientation, and Stevens-Johnson syndrome.

Aprepitant is an NK1 receptor antagonist developed by Merck. Aprepitant was approved by the FDA as an oral capsule in the United States in 2003. Aprepitant enhances the antiemetic activity of the 5-HT3 receptor antagonist ondansetron and the glucocorticoid dexamethasone against cisplatin-induced vomiting. Aprepitant can also inhibit the acute and delayed phase vomiting caused by cisplatin. The drug is a selective high-affinity antagonist of the human substance P neurokinin 1 (NK1) receptor.

Very good, but there are many groups of people who are not suitable for taking this drug. For example, patients who are taking drugs such as pimozide, terfenadine, astemizole, etc. are prohibited from taking aprepitant. Patients who are allergic to any component of aprepitant capsules are also prohibited from taking it. In addition, the elderly, children, pregnant women, and lactating women are prohibited from taking this drug.

Aprepitant is already on the market in China, but it has not yet been included in medical insurance. The financial burden for patients to buy the drug in hospital pharmacies is relatively heavy, but it is more cost-effective to obtain the drug through Medical Companion Travel, which can reduce the financial burden. It is recommended that patients purchase drugs overseas through Medical Companion Travel. There are many versions, and direct mail from the pharmaceutical factory can guarantee that the drug is genuine. For more information, patients can consult the medical companion passenger service staff.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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