阿瑞匹坦（Aprepitant）会耐药吗？治疗时要注意什么

Aprepitant has a unique mode of action. It is a selective and high-affinity antagonist of the receptor for the human substance PNeurokinin1 (NK1). The drug has been approved by the US FDA for the treatment and prevention of postoperative nausea and vomiting, or in combination with other antiemetics to prevent nausea and vomiting caused by chemotherapy drugs. Will it be resistant? What should I pay attention to during treatment?

Aprepitant resistance

Resistance to Aprepitant. Because each patient's physical condition is different, the time it takes for them to develop resistance, the manifestations of resistance, and the treatment plan after drug resistance develops after receiving Aprepitant treatment will all be different. How long it takes for drug resistance to develop after treatment with Aprepitant is mainly determined by the patient's condition, personal constitution, and tolerance to the drug.

If a patient develops drug resistance during treatment with aprepitant, he or she should go to the hospital immediately for a detailed physical examination. The doctor will recommend the best treatment plan based on the patient's physical condition. Patients who are resistant to aprepitant should not blindly use other drugs for treatment, because this may produce some adverse reactions and affect the condition.

Pay attention to drug interactions when using Aprepitant. This drug can produce a dose-dependent inhibition of cytochrome P450 isoenzyme 3A4 (CYP3A4), which increases the blood concentration of these drugs, which may cause serious or life-threatening adverse reactions. Therefore, patients should not use such drugs at the same time during aprepitant treatment.

Patients should take effective contraceptive measures during aprepitant treatment to avoid fetal harm. If a patient is pregnant, aprepitant should be treated with this medicine only if the potential benefits outweigh the possible risks to the mother and woman. Breastfeeding patients should stop taking the medication or stop breastfeeding.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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