肿瘤化疗后应该怎么服用阿瑞匹坦胶囊

Anti-cancer drug capsules are imported drugs approved by the FDA. Compared with other chemotherapy and antiemetic drugs, they have better efficacy, fewer adverse reactions and good tolerance. Aprepitant capsule is the first high-selective affinity antagonist of substance P neurokinin 1 (NK-1) receptor; it can occupy the NK-1 receptor in the brain through the blood-brain barrier, inhibit the acute phase and delayed phase vomiting caused by cisplatin, and enhance the antiemetic activity of the 5-hydroxytryptamine receptor 3 (5-HT3) receptor antagonist ondansetron and glucocorticoids against cisplatin-induced vomiting.

How should you take aprepitant capsules after cancer chemotherapy:

1. In the combined treatment regimen of aprepitant capsules with a glucocorticoid and a 5-HT3 antagonist, aprepitant was administered for 3 days.

2. The recommended dose of aprepitant is 125 mg orally administered 1 hour before chemotherapy (Day 1), and 80 mg orally once daily in the morning on Days 2 and 3.

3. Aprepitant can be taken with or without food. No dosage adjustments are required for patients of different ages, genders, races and body mass indexes (BMI).

4. Patients with severe renal insufficiency (light creatinine clearance and moderate hepatic insufficiency (Child-Pugh classification score 5-9 points)) do not need to adjust the dosage of aprepitant.

5. There is currently no clinical research data on the use of aprepitant in patients with severe hepatic insufficiency (Child-Pugh classification score >9 points).

Applicable and contraindication groups for taking aprepitant:

1. Suitable for patients who experience vomiting symptoms during chemotherapy;

2. Contraindications: People who are allergic to any component of aprepitant capsules; patients who are taking pimozide, terfenadine, astemizole and other drugs.

3. Pregnant women, the elderly, and children are not allowed to take this medicine. Pregnant women and lactating women are not allowed to take this medicine. The safety of this medicine is unknown for children, so it should be used with caution. There are no clear contraindications for the elderly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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