枢丹止吐效果如何？

Shudan (ondansetron hydrochloride injection), indicated as an antiemetic drug. Used for: ① Nausea and vomiting caused by cytotoxic drug chemotherapy and radiotherapy; ② Prevention and treatment of nausea and vomiting after surgery. Ondansetron is a selective 5-HT3 receptor antagonist. Although its mechanism of action has not been fully characterized, ondansetron is not a dopamine receptor antagonist. 5-HT3 type serotonin receptors are present in the periphery of the vagus nerve terminals and in the center of the chemoreceptor triggering zone in the postcentral area.

It is uncertain whether the antiemetic effects of ondansetron are mediated centrally, peripherally, or both. However, cytotoxic chemotherapy appears to be associated with the release of serotonin from enterochromaffin cells in the small intestine. In humans, urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion increases following cisplatin administration concurrent with the onset of vomiting. The released serotonin can stimulate vagal afferents through 5-HT3 receptors and trigger the gag reflex.

How effective is Shudan in antiemetics? The anti-emetic effect is good. Ondansetron hydrochloride tablets are anti-emetic drugs, specially used for nausea and vomiting caused by cytotoxic drug chemotherapy and radiotherapy; preventing and treating nausea and vomiting after surgery. It exerts antiemetic effects by antagonizing the 5-HT receptors of neurons located in the peripheral and central nervous system. The mechanism of nausea and vomiting after surgery is unknown, but it may be induced by a common pathway similar to cytotoxic drugs that cause nausea and vomiting. Shudan can still inhibit opioid-induced nausea, but its mechanism of action is still unclear. Due to the highly selective effect of Shudan, it does not have the side effects of other antiemetics, such as extrapyramidal reactions, excessive sedation, etc.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended hot articles: