阿瑞匹坦胶囊作用功效

Aprepitant (trade name: Italian-American) has a unique mode of action. It is a selective and high-affinity antagonist to the receptor of human substance P Neurokinin1 (NK1). Let’s learn about the functions of capsules.

Preclinical studies have shown that aprepitant can penetrate into the brain and bind to the brain's NK1 receptor. Preclinical studies have shown that aprepitant has a long-lasting effect on the central system and can inhibit cisplatin-induced vomiting in the acute and delayed phases, thereby enhancing the antiemetic 5-HT3-receptor antagonist ondansetron and the leather steroid dexamethasone against cisplatin-induced vomiting.

Aprepitant capsules, administered in combination with other antiemetic drugs, are indicated for the prevention of acute and delayed nausea and vomiting during initial and repeated treatment with highly emetogenic antineoplastic chemotherapy. After being launched on the market, aprepitant has been in the first-line recommended position in the anti-emetic regimen of chemotherapy drugs with high risk of vomiting, and its efficacy and safety have been clinically recognized.

Cancer has become the second leading cause of death in my country, and for many patients receiving chemotherapy, nausea and vomiting follow them like a nightmare. Professor Jiao Shunchang, chief physician of the Department of Medical Oncology at the General Hospital of the Chinese People's Liberation Army and a standing member of the Oncology Branch of the Chinese Medical Association, said that nausea and vomiting caused by chemotherapy are the most common adverse reactions of chemotherapy, which may lead to metabolic disorders, impaired body function, malnutrition, and even make patients refuse further chemotherapy, affecting patients' quality of life and anti-tumor treatment effects. How to solve this problem and provide guarantee for the smooth progress of tumor treatment is an urgent medical need that needs to be met. As a first-line drug and recommended drug for preventing nausea and vomiting caused by highly emetogenic anti-tumor chemotherapy, it has been unanimously recommended by authoritative European and American guidelines such as the National Comprehensive Cancer Network Clinical Application Guidelines (NCCN).

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.