默沙东阿瑞匹坦效果怎么样？

How effective is MSD?

In a randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase III clinical study, the effect of aprepitant treatment regimen and standard treatment regimen for the prevention of chemotherapy-induced vomiting (CINV) was compared in 412 Chinese patients receiving chemotherapy (including cisplatin 70 mg/m2).

The aprepitant regimen included aprepitant at a dose of 125 mg on day 1 and 80 mg/day on days 2 and 3, in combination with granisetron (3 mg intravenously on day 1) and dexamethasone (6 mg on day 1 and 3.75 mg on days 2 and 4). Standard treatment consists of placebo combined with granisetron (3 mg intravenously on day 1) and dexamethasone (10.5 mg on day 1, 7.5 mg on days 2 to 4).

In Cycle 1, the antiemetic activity of aprepitant was evaluated during the acute phase (0-24 hours after cisplatin treatment), the delayed phase (25-120 hours after cisplatin treatment), and the total observation period (0-120 hours after cisplatin treatment). The primary efficacy assessment was based on the proportion of patients who reported a complete response (no vomiting and no use of rescue therapy) during the total observation period. Secondary efficacy estimates were based on the proportion of patients who reported complete remission in the acute and delayed phases, the absence of vomiting during the overall observation period, acute and delayed phases, and the absence of an impact on daily life and time to first emetic episode during the overall observation period. Exploratory evaluation was based on the proportion of patients who reported complete control and overall control in the acute phase, delayed phase, and total observation period, and no significant nausea and no nausea in the total observation period.

The therapeutic benefits of the treatment regimen were numerically superior to those of the standard treatment regimen.

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