布地奈德缓释胶囊治疗效果怎么样？怎么服用布地奈德缓释胶囊？

Budesonide extended-release capsules, widely used to treat Crohn's disease, are anti-inflammatory corticosteroids with very high affinity for receptors. The biggest advantage of this drug is that it significantly reduces the inhibitory effect of traditional hormone preparations on the adrenal cortex and reduces the side effects of traditional hormones. Today let’s take a closer look at the effects of treatment? How to take budesonide extended-release capsules?

About 90% of budesonide extended-release capsules are metabolized in the liver during the first pass, and 90% are bound to albumin. There is significantly less hormone that can be absorbed into the blood system. The safety profile is very good. About 1,000 patients with mild to moderate active Crohn's disease in the ileum and ascending colon participated in Entocort In the five clinical trials of EC, the CDA scores of these patients before treatment were between 272 and 290. The trial stipulated that the standard for "disease remission" was that the CDA (Corhn's disease activity index) score was lower than or equal to 150. Another advantage of budesonide sustained-release capsules is that the active ingredient is released in the intestine, which is the area mainly affected by Crohn's disease. Budesonide sustained-release capsules have been granted orphan drug status by the European Union and the U.S. FDA. Currently, budesonide sustained-release capsules have completed Phase II clinical studies for IgA nephropathy, and are planning to conduct Phase III clinical studies.

The dosage of budesonide extended-release capsules for different periods of time is different. For the treatment of adults with mild to moderately active Crohn's disease, 9 mg daily for up to 8 weeks; for children aged 8 to 17 years and weighing more than 25 kg: 9 mg once daily for up to 8 weeks, then 6 mg every morning for 2 weeks. When used to maintain clinical remission in mild to moderate Crohn's disease, the dose for adults is 6 mg daily, discontinued after 3 months, for a maximum of 3 months. Patients must follow the doctor's instructions and do not change the dosage and usage at will.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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