埃索美拉唑四联疗法治疗幽门螺杆菌相关性胃溃疡的疗效

Gastric ulcer is a common chronic disease in gastroenterology. The main clinical manifestations are rhythmic and cyclic gastric pain and significantly elevated levels of inflammatory mediators such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). With the changes of the times and changes in diet, the incidence of gastric ulcers is getting higher and higher, and some patients are susceptible to factors such as drinking and fatigue due to large ulcer areas and deep invasion sites, which can lead to upper gastrointestinal bleeding or even gastric perforation and death. At present, it is clinically believed that the main cause of gastric ulcer is Helicobacter pylori (HP) infection, pepsin and gastrointestinal hormone imbalance. Quadruple therapy based on similar proton pump inhibitors is often used. Next, the editor will introduce to you the efficacy of esomeprazole quadruple therapy in the treatment of Helicobacter pylori-related gastric ulcer.

83 patients diagnosed with gastric ulcer were included in this study and randomly divided into groups. 42 patients in the control group received omeprazole quadruple therapy, and 41 patients in the experimental group received esomeprazole quadruple therapy. The clinical effects of the two groups were compared. Results After treatment, the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in both groups were lower than before treatment, and the improvement in the experimental group was more significant than that in the control group, and the difference was statistically significant (F<0.05). After treatment, the levels of somatostatin (SS) in both groups were higher than before treatment, and the levels of gastrin (GAS) were lower than before treatment, and the improvement in the experimental group was more significant than that in the control group, and the difference was statistically significant (P<0.05). ); The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (p<0.05). Conclusion: Esomeprazole quadruple therapy has significant clinical effect in treating patients with HP-infected gastric ulcer, and can better improve the levels of inflammatory mediators and gastrointestinal hormones.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.