非达霉素(Dificid)应该怎么服用

Fidaxomicin is a macrolide antibiotic specifically used to treat Clostridium difficile-associated diarrhea (CDAD), and is suitable for adults and children over 6 months of age. The drug is currently on the market in many countries, but it has not yet been launched in China as of September 2025.

How to take fidaxomicin (Dificid)

Adult Medication Guide

1. The standard dose is 200 mg orally twice a day.

2. The course of treatment is 10 days, and the entire course of treatment should be completed.

3. It can be taken with food or on an empty stomach without affecting the efficacy.

4. The tablet should be swallowed whole and should not be chewed or crushed.

Pediatric Medication Guide

1. Children aged 6 months to under 18 years old need to be dosed according to body weight.

2. Those who weigh ≥12.5kg and can swallow tablets should use 200mg tablets.

3. Weight 4-7kg: 80mg/time; 7-9kg: 120mg/time.

4. Weight 9-12.5kg: 160mg/time; ≥12.5kg: 200mg/time.

Principles for handling missed doses

1. Take the dose immediately when you remember it, unless it is close to the time for the next dose.

2. Do not take double doses at the same time.

3. Keep taking medication regularly. If you frequently miss doses, you should contact your doctor in time.

Dose for special groups

1. The elderly usually do not need to adjust the dose.

2. Patients with renal insufficiency do not need to adjust the dose.

3. People with liver insufficiency are advised to use it with caution.

4. Pregnant women need to weigh the pros and cons before using it.

What side effects will Fidaxomicin (Dificid) cause

Mild side effects

Common gastrointestinal reactions

1. The incidence of nausea is about 11%, usually mild.

2. The incidence of vomiting is about 7%, which is mostly tolerable.

3. The incidence of abdominal pain is about 6%. It is recommended to take it after meals.

4. The incidence of gastrointestinal bleeding is about 4%, and close observation is required.

Abnormal reactions in the blood system

1. The incidence of anemia is about 2%, and it is recommended to monitor hemoglobin.

2. The incidence of neutropenia is about 2%, and regular examination is required.

3. Thrombocytopenia is occasionally reported, which should be taken seriously.

4. If signs of infection appear, seek medical treatment promptly.

Abnormal liver function reactions

1. The incidence of elevated transaminases is about 5%.

2. Elevation of alkaline phosphatase occasionally occurs.

3. It is recommended to monitor liver function during treatment.

4. Severe liver damage is rare but requires vigilance.

Allergic reaction

1. The incidence of rash is about 5%, including maculopapular rash.

2. Itching occasionally occurs and can be treated symptomatically.

3. Angioedema is rare but requires urgent treatment.

4. If you have difficulty breathing, you need to stop taking the medicine immediately and seek medical treatment.

Other common reactions

1. The incidence of fever is about 13%, more common in children.

2. The incidence of constipation is about 5%, and the diet can be adjusted.

3. Headaches are occasionally reported, usually temporary.

4. Fatigue may occur, so pay attention to rest.

Serious adverse reactions

1. Severe allergic reactions require immediate discontinuation of the drug.

2. Severe reduction of blood cells requires medical intervention.

3. Be wary of reinfection with Clostridium difficile.

4. If serious side effects occur, you should seek medical treatment in time.