阿法脱氧核糖核酸酶吸入剂的副作用如何缓解

Alfa deoxyribonuclease inhalation is an important drug in the treatment of cystic fibrosis and can effectively improve patients' lung function. Despite its remarkable efficacy, some adverse reactions may occur during use, and patients should be aware of these side effects and how to deal with them. This article will introduce in detail the common side effects, mitigation measures and standardized medication guidance of alfa deoxyribonuclease inhalation.

Side effects of alfa deoxyribonuclease inhalant

As an inhaled preparation, its side effects are mainly concentrated on the respiratory system and local reactions. Clinical data show that most of these adverse reactions are mild to moderate, but they still need to be taken seriously.

Respiratory system reaction

Voice change is the most common side effect, with a high incidence rate. Some patients may develop upper respiratory tract irritation symptoms such as laryngitis and pharyngitis. Although dyspnea is uncommon, it requires special attention, especially in patients with pre-existing severe lung function impairment.

Local irritation symptoms

Chest pain and rash are the more common local reactions. Chest pain usually presents as mild discomfort and is often associated with inhalation procedures. The rash is mostly mild and often appears on the face or areas in contact with the drug.

Other systemic reactions

Eye and nasal symptoms such as conjunctivitis and rhinitis occasionally occur, and a small number of patients may develop fever, which is usually transient and can resolve on its own without special treatment.

How to alleviate the side effects of alfa deoxyribonuclease inhalation

Taking appropriate mitigation measures for different side effects can significantly improve patients' medication experience and treatment compliance.

Respiratory symptom management

Voice changes can be relieved by adequate mouthwash after inhalation. When the symptoms of laryngitis or pharyngitis are obvious, you can consider using normal saline aerosol inhalation. Patients with dyspnea should have their lung function evaluated and their dosage regimen adjusted if necessary.

Local symptom management

Chest pain patients should check whether the inhalation technique is correct and adjust the inhalation intensity. Use gentle skin care products for rashes and avoid scratching. Seek medical attention if symptoms persist or worsen.

Coping with systemic symptoms

Fever patients are advised to drink more water and monitor changes in body temperature. Conjunctivitis can be relieved with artificial tears. These symptoms are usually transient, and if they persist, other causes should be considered.

Usage Guidelines for Alfa DNase Inhalation

Patients should use Alfa DNase Inhalation under the guidance of a doctor.

Correct inhalation method

It is recommended to use a special jet atomizer or a vibrating mesh atomizer. Check the properties of the medicine before each inhalation. Discard if cloudy or discolored. Clean the nebulizer thoroughly after inhalation to avoid drug residue.

Dosage and treatment course

The standard dose is 2.5 mg once a day. Treatment should be continued and should not be interrupted at will. If you miss a dose, you should take it as soon as possible. If it is close to the next dose time, skip the dose.

Usage for special groups

Pediatric patients need to be assisted by an adult to complete inhalation. Data on the use of medications in pregnant women are limited, and the pros and cons need to be weighed. No dose adjustment is required in elderly patients. All patients should be regularly evaluated for changes in lung function.

By understanding the side effect characteristics of alfa deoxyribonuclease inhalation, taking targeted mitigation measures, and strictly following the medication guidelines, patients can minimize the impact of adverse drug reactions while improving lung function.