子宫内膜异位症药物艾拉戈克钠的疗效和不良反应处理

Introduction: Orilissa/Elagolix is ​​an oral GnRH (gonadotropin-releasing hormone) receptor antagonist, mainly used to treat moderate to severe pain related to endometriosis. This article mainly talks about the therapeutic effect, mechanism of action, medication for special groups, side effects and management of Elagog sodium.

Treatment Effectiveness

In a double-blind, randomized, 6-month Phase III trial, the effect of Elagog sodium compared with placebo was evaluated in women with surgically diagnosed endometriosis. Its primary efficacy endpoint was the proportion of women with dysmenorrhea and nonmenstrual pelvic pain who had a clinical response. The results showed that women treated with Elagog sodium were significantly better than the placebo group in improving dysmenorrhea and non-menstrual pelvic pain.

Mechanism of action

Elagog sodium competitively binds to the gonadotropin-releasing hormone (GnRH) receptor in the pituitary gland, inhibiting its signal transduction, resulting in dose-dependent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby reducing the blood concentration of ovarian sex hormones, estradiol and progesterone, achieving the effect of treating endometriosis.

Usage in Special Populations

Patients with mild liver impairment do not need to adjust the dose. The treatment duration for patients with moderate liver impairment is limited to 6 months. Patients with severe liver impairment are prohibited from using Elagog Sodium. Elagog sodium should be used with caution or contraindicated in pregnant women, patients with osteoporosis, and patients with severe liver damage.

Side Effects and Management

Common side effects of Elagog sodium include nausea, headache, hot flashes, insomnia, irritability, mood changes, hair loss, uterine bleeding, menorrhagia, anxiety, joint pain, fatigue, etc. In addition, long-term use of Elagog sodium may cause osteoporosis and increase the risk of fractures, especially in menopausal women.

Side effects such as hot flashes and headaches may require symptomatic medications or non-drug therapies. For mood-related side effects, psychological counseling or support may help patients manage mood swings. If side effects are severe, your doctor may consider adjusting the dose or changing your treatment regimen. During treatment, doctors will closely monitor patients for side effects and adjust treatment plans based on the situation.

Although it has shown significant efficacy in the treatment of endometriosis, its use should follow the guidance of a doctor and be aware of possible adverse reactions. If you have any questions or need further guidance, please consult a medical professional promptly.