恩瑞格主治什么？

It is developed by Novartis and is currently the only oral iron ion chelator. So, what does Enrig treat?

Indications of Enrig:

1. Patients with chronic iron overload transfusion hemosiderinosis secondary to blood transfusion who are 2 years old or older will develop symptoms of chronic iron overload when serum ferritin continues to be >1000 L. At this time, iron chelation therapy should be started.

2. Iron chelators can also be given to patients undergoing ASCT when iron overload occurs.

3. It can be used to treat reversible renal insufficiency caused by Fanconi syndrome.

How to use Enrig:

The recommended starting daily dose of Enrig is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (ie, more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered.

For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.

In patients who have already responded well to deferoxamine therapy, an initial dose of Enriga equivalent to half the deferoxamine dose may be considered. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, may start at 20 mg/kg if switched to Enriga.)

In November 2005, Enrig was approved by the FDA for use in patients 2 years and older with chronic iron overload caused by blood transfusions.

In December 2012, Enrig was approved by the European Commission for the treatment of chronic iron overload in patients aged 10 years and above with non-transfusion-dependent thalassemia (NTDT) syndrome who require chelation therapy due to contraindications or insufficiency of deferoxamine mesylate therapy.

On January 23, 2013, the FDA approved a new indication for the treatment of chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) aged 10 years and older.