地拉罗司怎么用？

During the use of dispersible tablets, if the patient starts using it without knowing its usage and dosage, it is very likely to cause adverse reactions. If you do not take medication as prescribed, it will do a lot of harm to your body without any benefit. So, what is the dosage of deferasirox dispersible tablets?

Dosage and usage of deferasirox dispersible tablets: (Starting dose) The recommended starting daily dose of deferasirox dispersible tablets is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.

In patients who have responded well to deferoxamine therapy, an initial dose of deferasirox dispersible tablets equivalent to half the deferoxamine dose may be considered. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, may start with deferasirox dispersible tablets at 20 mg/kg.) Preparation: Deferasirox dispersible tablets should be taken on an empty stomach at least 30 minutes before a meal, once daily, preferably at the same time each day. Tablets should not be chewed or swallowed whole.

Deferasirox dispersible tablets should not be taken together with aluminum-containing antacids, and the dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200 mL) by stirring until a clear suspension is obtained and drink it. The remaining drug must be added to a small amount of water, apple juice or orange juice and mixed well before taking. Dissolving in carbonated drinks and milk is not recommended as it can cause foaming and slow dispersion.

Deferasirox dispersible tablets are used to treat chronic iron overload caused by frequent blood transfusions (monthly administration of concentrated red blood cells ≥7 mL/kg) in patients with β-thalassemia older than 6 years old. For iron overload caused by children under 6 years old and other transfusion-dependent diseases, it is recommended to use with caution based on the specific conditions of the patient.

The above is the usage and dosage of dispersible tablets. It is recommended that patients read the instructions first and choose whether to use it based on their own conditions. Hope it helps everyone.