去纤苷Defibrotide的使用方法是什么？用多长时间见效

Defibrotide is a safe and effective drug for the prevention and treatment of hepatic veno-occlusive disease (HVOD) after hematopoietic stem cell transplantation (HSCT). In clinical trials, heparin was used to prevent diseases such as hepatic veno-occlusion while greatly increasing the risk of bleeding. However, defibrotide alone or in combination with heparin has a very low incidence of side effects and has achieved good results in preventing HVOD. How to use that? How long does it take to take effect?

How to use Defibrotide

The recommended dose of Defibrotide for the treatment of adult and pediatric patients is: 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The dose should be determined based on the patient's baseline weight, defined as the patient's weight before preparation for HSCT (hematopoietic stem cell transplantation).

Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic veno-occlusive disease have not resolved after 21 days, continue Defibrotide treatment until resolution of hepatic veno-occlusive disease or for a maximum of 60 days. The actual dosage of Defibrotide can be determined based on the patient's disease stage and tolerance to the drug. Patients should strictly follow the doctor's instructions when taking medication, so as to obtain better therapeutic effects.

The patient's disease progression, personal constitution, and tolerance to drugs are different, and the efficacy and time to take effect after receiving Defibrotide treatment will also be different. Therefore, the time to take effect of Defibrotide cannot be accurately given. How long it takes for the patient to see the effect after treatment with Defibrotide is mainly determined by the patient's personal constitution, disease progression, and tolerance to the drug. Clinical trials have shown that Defibrotide has significant efficacy and can prolong the survival of patients and reduce their pain.

The above is an introduction to how to use Defibrotide and how long it takes to take effect. If patients want to know more about Defibrotide drug information (such as purchasing channels, drug prices, precautions, etc.), they can consult the medical companion travel service at any time.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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