去纤苷哪里可以买到？

It is suitable for the treatment of adults and children with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT). Where can I buy defibrotide?

Purchasing channels for defibrotide: According to Medical Companion Travel, defibrotide has been marketed abroad. The price of defibrotide listed abroad is about 22,000. Due to the floating exchange rate, the price is different. Please consult Medical Companion Travel for the specific price!

If you need defibrotide and it is inconvenient to go abroad, the most reliable way is to purchase it through a regular domestic overseas medical service institution, which will sign a guarantee contract for you. The medicine and money will not be handled by you, and will be mailed to the patient by direct mail, guaranteeing 100% authenticity!

The mechanism of action of defibrinoside:

In vitro, defibrinoside enhances the enzymatic activity of plasmin, which hydrolyzes fibrin clots. Studies evaluating the pharmacological effects of defibrotide on endothelial cells (ECs) have been primarily conducted in human microvascular endothelial cell lines.

In vitro, defibrinoside increases tissue plasminogen activator (t-PA) and thrombomodulin expression and decreases von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) expression, thereby reducing EC activation and increasing EC-mediated fibrinolysis. Defibrotide protects ECs from chemotherapy, tumor necrosis factor-α (TNF-α), serum starvation, and perfusion-induced injury.

In addition, the incidence rate of grade 3-4 adverse reactions related to patients during use was 7%, mainly hypotension, pulmonary and gastrointestinal bleeding, and abdominal cramps. Only 4% of patients stopped treatment due to side effects. In other words, the side effects of defibrotide are usually mild, and patients do not need to worry too much.

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