非布索坦（非布司他）可以根治痛风吗？

(Febuxostat) is a non-purine xanthine oxidase inhibitor. Its launch provides a new option for gout patients. It has been approved by the European Union and the United States for the treatment of gout and hyperuricemia. So, can febuxostat cure gout?

The answer is no. Although febuxostat can reduce blood uric acid levels, it can only provide relief but cannot achieve a complete cure. In this regard, patients must strictly follow the doctor's instructions or instructions during the actual medication period. In terms of diet, it is best not to eat foods with high purine content such as fish and shrimp. In daily life, patients should also be careful not to overwork themselves and avoid catching wind and cold. If you fail to pay attention to the above points, then the patient may still have a certain dose that causes gout attacks.

However, judging from the results of previous clinical trials, the effect of febuxostat in treating gout is worthy of recognition. The phase II clinical trial of febuxostat is a randomized, double-blind, placebo-controlled trial lasting 28 days. The doses of febuxostat were selected in three groups: 40 mg/d, 80 mg/d, and 120 mg/d, and colchicine was used to prevent acute attacks of gout. 153 gout patients were enrolled, 89% of whom were male, and the average blood uric acid was ≥8.0 mg/dL. The primary endpoint of the trial is the proportion of blood uric acid <6.0mg/dL at 28 days. The proportions of the febuxostat 40mg/d, 80mg/d, and 120mg/d groups reaching the primary endpoint were 56%, 76%, and 94% respectively, which were significantly higher than the placebo group (P<0.001).

At 28 days, the average baseline blood uric acid reduction proportions in the three groups were 37%, 44%, and 59% respectively, and the placebo group was 2%. In terms of acute gout attacks, the febuxostat 40 mg/d group was similar to the placebo group, with rates of 35% and 37% respectively, while the 80 mg/d and 120 mg/d groups had higher rates, 43% and 55% respectively, which may be related to the rapid decrease in blood uric acid levels and large fluctuations in blood uric acid concentrations.

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