非布索坦片可以长期吃吗？

(febuxostat) is a new, non-purine island-acting, selective inhibitor of xanthine oxidase, a key enzyme that promotes uric acid production. This product is completely absorbed after oral administration. The blood concentration reaches the peak 1 hour after administration. The half-life is 8 hours. Most of the drugs in the body exist in free form, and 30% of the administered dose is excreted through the kidneys in the form of original drug.

Can gout patients take febuxostat tablets for a long time?

In principle, Febuxostat tablets can be taken for a long time, and they need to be taken consistently, so that they can continue to benefit from it and achieve the purpose of treating gout. However, the specific length of time to take it depends on the progress of the patient's condition. Under normal circumstances, patients can take febuxostat tablets for about 6 months.

Febuxostat (Febuxostat) is suitable for the long-term treatment of hyperuricemia with gout symptoms, but is not recommended for the treatment of patients with asymptomatic hyperuricemia; it can be used in patients with gout who cannot tolerate allopurinol and who have failed allopurinol treatment. The recommended dose for adults is 80 mg once daily on an empty stomach. Febuxostat has a pregnancy safety grade of C and should be used with caution in pregnant and lactating women. There is no need to adjust the dose in elderly patients. There is a lack of research on the safety and effectiveness of the drug in children and adolescents under 18 years old, so it is not recommended. No dose adjustment is required in patients with mild to moderate renal impairment, but use is not recommended in patients with severe renal impairment.

In clinical trials, although most patients showed good tolerance to the drug, the drug still produced certain side effects. The main adverse reactions included abnormal liver function, nausea, joint pain, etc. These adverse reactions can generally be effectively alleviated after a series of symptomatic treatments, but patients still need to pay high attention. When the patient's adverse reaction symptoms worsen, the patient needs to go to the hospital for treatment.

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