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(febuxostat) is a new non-purine xanthine oxidase selective inhibitor developed by Teijin Company of Japan. It was approved for marketing in the EU in May 2008 under the trade name Adenuric. In February 2009, the drug was approved by the US FDA for marketing under the trade name Uloric. This product can reduce the level of uric acid in the body and is clinically used to treat hyperuricemia and gout. So, when is the best time to take febuxostat?

Since febuxostat is not affected by food, patients can take it before or after meals, and patients can make a decision based on their actual situation. Febuxostat is an inhibitor of xanthine oxidase and can increase the blood concentration of drugs metabolized by xanthine oxidase, such as theophylline and azathioprine. Therefore, the above drugs should be avoided when taking febuxostat. When they must be used, the dosage of the above-mentioned drugs should be reduced and their blood drug concentrations in the body should be measured regularly to avoid serious adverse reactions. Antacids will affect the absorption rate of febuxostat but not its absorption, so there is no need to increase the dosage when taking them at the same time.

Febuxostat (Febuxostat) has a pregnancy safety rating of C and should be used with caution in pregnant and lactating women. There is no need to adjust the dose in elderly patients. There is a lack of research on the safety and effectiveness of the drug in children and adolescents under 18 years old, so it is not recommended. No dose adjustment is required in patients with mild to moderate renal impairment, but use is not recommended in patients with severe renal impairment.

In clinical trials, patients showed good tolerance, and the main adverse reactions included abnormal liver function, nausea, joint pain, etc. Although these adverse reactions can be effectively alleviated after a series of symptomatic treatments, patients still need to pay high attention. When the patient's adverse reaction symptoms worsen, the patient needs to go to the hospital for treatment to avoid more serious adverse events.

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