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Tablet instructions

[Drug name] Febuxostat tablets

[Drug Ingredients] The main ingredient of febuxostat is febuxostat.

【Character】Febuxostat is a film-coated tablet, which appears white or off-white after the coating is removed.

[Mechanism of action] Febuxostat is an effective non-purine selective inhibitor of xanthine oxidase XO. It achieves the therapeutic effect of reducing serum uric acid by selectively inhibiting xanthine oxidase.

[Indications] Febuxostat is a xanthine oxidase (XO) inhibitor and is suitable for the long-term treatment of hyperuricemia with gout symptoms.

【Usage and Dosage】

1) Febuxostat is recommended at 40 mg or 80 mg once daily. The recommended starting dose of febuxostat is 40 mg once daily. For patients who do not achieve serum uric acid (sUA) less than 6 mg/dL 2 weeks after taking 40 mg, febuxostat 80 mg is recommended.

2) Can be administered without food or using antacids.

3) No dose adjustment is required when administering febuxostat to patients with mild to moderate renal or hepatic impairment.

[Adverse reactions] Weakness, chest pain, discomfort, edema, fatigue, abnormal mood, gait disorder, influenza symptoms, gas, pain, and thirst.

[Contraindications] This product is contraindicated in patients taking azathioprine, mercaptopurine or cholophylline.

【Notes】

1) Gout flare: An increase in flare-ups of gout is often observed during initiation of antiuricemic drugs, including febuxostat. If a gout attack occurs during treatment, febuxostat does not need to be discontinued. Preventive treatment (i.e., initiating treatment with NSAIDs or colchicine) may be beneficial until 6 months of age.

2) Cardiovascular events: In clinical trials, a higher incidence of cardiovascular embolic events was observed in patients treated with febuxostat than with allopurinol. Monitor for signs and symptoms of MI and stroke.

3) Elevated liver enzymes: Elevated transaminases have been observed in treated patients. Monitor liver function tests regularly.