非布司他耐药后方案

Everyone cannot avoid getting sick in life, especially gout. Once an attack occurs, it will cause great pain to the patient. To treat gout, you must choose the correct medication to achieve better therapeutic effects. It is a drug used to treat gout. Of course, drug resistance will occur. Febuxostat is used to treat gout. For gouty arthritis, gout in the elderly, hyperuricemia, pseudogouty arthritis, tophi, and hereditary hyperuricemia, the recommended starting dose is 40 mg once a day. If the blood uric acid level is still not less than 6 mg/dl (approximately 360 μmol/L) after 2 weeks, the recommended dose is increased to 80 mg once a day. There is no need to consider the influence of food and antacids when administering.

Many patients often develop drug resistance while taking febuxostat, and drug resistance is also very common. The development of drug resistance while taking febuxostat leads to gout attacks. This situation is because changes in blood uric acid levels cause urate deposits in tissues to be mobilized, thus causing gout attacks. To prevent gout attacks during the initial period of taking febuxostat, it is recommended to take nonsteroidal anti-inflammatory drugs or colchicine at the same time. The benefits of preventive treatment can last up to 6 months. If diagnosed early and patients are treated as prescribed, modern treatments can allow most patients to live normal lives. For advanced patients, tophi can be dissolved, joint function can be improved, and renal dysfunction can also be improved. People with gout who first develop symptoms before the age of 30 have a more severe condition. Approximately 20% of gout patients develop uric acid or calcium oxalate stones. Complications include urinary tract obstruction and infection, as well as secondary tubulointerstitial lesions. Untreated progressive renal dysfunction is often associated with hypertension, diabetes or other kidney diseases, which can further lead to urate excretion disorders, which not only accelerates the pathological process in the joints, but is also the greatest threat to life.

To sum up, the drug febuxostat can cause drug resistance, but this drug is very effective in treating gout, so the drug is also recognized by patients. Therefore, patients with gout can use febuxostat for treatment under the guidance of a doctor. When drug resistance occurs, you must not change the dressing or increase the dose of the original drug without permission. You should suspend the medication and contact the attending doctor in time to obtain a new treatment plan.