非布索坦能根治痛风吗？

Gout occurs due to excessive production of uric acid in the body and reduced kidney clearance ability. Uric acid accumulates in the body, leading to the deposition of urate crystals in joints and various organs. Therefore, the usual treatment for gout is to promote uric acid excretion and inhibit uric acid production, and take appropriate measures to improve related symptoms. The production of uric acid in the body is related to purine metabolism. In the final step of purine metabolism, hypoxanthine generates xanthine under the action of xanthine oxidoreductase (XOR), and then further generates uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. It is the latest XOR inhibitor developed in the world. It acts on this oxidase highly selectively, reducing the synthesis of uric acid in the body and lowering the concentration of uric acid, thereby effectively treating gout.

Febuxostat is an effective non-purine selective inhibitor of xanthine oxidase (XO). By selectively inhibiting xanthine oxidase, it can achieve the therapeutic effect of reducing serum uric acid. Uric acid is the end product of purine metabolism and is produced in the cascade reaction of hypoxanthine → xanthine → uric acid. Each step of the conversion is catalyzed by xanthine oxidase. Febuxostat has been shown to effectively inhibit both oxidized and reduced forms of xanthine oxidase. Febuxostat at therapeutic concentrations does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely guanine deaminase, hypoxanthine guanine phosphoribosyltransferase, orotate phosphoribosyltransferase, orotate monophosphate decarboxylase, or purine nucleoside phosphorylase.

Since its launch, Febuxostat has quickly occupied the gout market with its good therapeutic effect and low side effects. Febuxostat can quickly reduce blood uric acid levels without affecting other metabolic processes in the body. However, gout is a relatively common disease, and the treatment cycle is relatively long. Therefore, during the treatment of gout, patients must take the medicine patiently as directed by the doctor, and are not allowed to increase or decrease the dosage without permission to avoid causing other discomforts. So, can febuxostat cure gout? Theoretically, it is impossible. Just like a common cold, being cured this time does not mean that you will not catch another cold in the future. For gout, it can only be cured clinically but cannot achieve a radical cure.