What are the precautions for using canakinumab?

(Canakinumab) is a human monoclonal antibody that can selectively inhibit IL-1β, significantly reduce systemic CRP and other inflammatory marker levels, and is well tolerated. It is currently mainly used to treat inflammatory diseases caused by hereditary IL-1β, such as Muckle-Wells syndrome. A study has enrolled 17,200 patients with stable myocardial infarction and persistently elevated hsCRP levels. They were randomly divided into canakinumab treatment groups and control groups. They were followed up for 4 years. The primary endpoints were non-fatal myocardial infarction, stroke, cardiovascular death, total mortality, adverse events, etc. The trial is currently ongoing. Canakinumab in acute myocardium

A large trial in secondary prevention of infarction is also underway. So, what are the precautions for using canakinumab?

Precautions when using canakinumab

1. Simultaneous use of TNF-alpha or IL-1 antagonists.

2. If serious infection occurs, please interrupt treatment.

3. May increase the risk of lymphoma.

4. May weaken the defense against malignant tumors.

5. Macrophage Activation Syndrome (MAS) is a known life-threatening disease that may develop with rheumatic diseases, especially SJIA. According to clinical trials, canakinumab does not increase the incidence of MAS.

6. In individual cases, unusual or opportunistic infections include aspergillosis, atypical mycobacterial infections, cytomegalovirus, herpes zoster; mainly upper respiratory tract infections, and in some cases serious infections. A causal relationship between treatment and infection cannot be excluded.

Also note

The editor of Medical Companion Travel finally recommends that patients who are taking canakinumab should follow the doctor's instructions and use the medicine correctly. Everyone's physical fitness and condition are different. A doctor should formulate the most accurate medication plan based on your examination results. Do not change the drug dosage and medication time on your own to avoid delaying your own treatment.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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