阿福他酶α有几种规格?多少钱?

Afotalase α is an enzyme replacement therapy drug developed by Alexion Pharmaceuticals of the United States, with the trade name Strensiq. The drug is available in various strengths, including 18mg/0.45mL, 28mg/0.7mL, 40mg/mL and 80mg/0.8mL, among which the price of 18mg/0.45mL is approximately US$13,210. Afotalase α requires subcutaneous injection, and clinical studies have shown that it can significantly improve bone development and survival rates of patients.

Afotalase alfa is available in several strengths

There are currently four main strengths available, suitable for patients of different weights and age groups. The dosage and concentration of each specification are different, and the doctor will choose the appropriate treatment plan according to the patient's specific situation.

18mg/0.45mL specification

18mg/0.45mL is one of the commonly used specifications of aftase alpha, which is suitable for patients with lighter body weight or treatment plans that require lower doses. This format typically contains single-dose prefilled syringes per box for patient convenience.

28mg/0.7mL specification

The 28mg/0.7mL specification is suitable for patients with medium weight. Its concentration is the same as 18mg/0.45mL, but the single injection volume is larger, which can reduce the frequency of injections.

40mg/mL and 80mg/0.8mL specifications

40mg/mL and 80mg/0.8mL specifications are suitable for heavier patients, especially adult or adolescent patients. The 80mg/0.8mL strength is not suitable for patients weighing less than 40kg to avoid the risk of overdose.

The various specifications of aftase alpha are designed to meet the treatment needs of different patient groups. Doctors will select the appropriate dose based on the patient's weight, disease severity and tolerance.

How much does different specifications of aftase α cost?

The price of aftase α varies depending on the specifications, and it has not yet been officially approved for marketing in China. Patients usually need to purchase it through overseas channels.

18mg/0.45mL specification price

The price of 18mg/0.45mL/box of aftase α is approximately US$13,210, which is one of the commonly used clinical specifications. Adult patients usually require 2-3 boxes per month, and long-term treatment costs are higher.

Prices of other specifications

The prices of 28mg/0.7mL, 40mg/mL and 80mg/0.8mL specifications vary due to market fluctuations and regional differences. Due to the higher dosage, the price of a single box of 80mg/0.8mL is usually higher.

The high price of aftase alpha limits the accessibility for some patients, and the rare disease drug market is looking forward to more economical alternatives or medical insurance coverage policies in the future.

Precautions for aftase α

As a biological agent, aftase α must be used in strict compliance with medical instructions, storage conditions and injection methods to maximize the efficacy and reduce adverse reactions.

Management of injection site reactions

Afotalase alfa requires subcutaneous injection. Common injection site reactions include erythema, pain and itching. It is recommended to rotate the injection site (abdomen, thigh, upper arm, etc.) to avoid local fat atrophy.

Allergic reaction monitoring

Some patients may experience allergic reactions, such as difficulty breathing, nausea or rash. If a severe allergic reaction occurs, stop taking the medicine immediately and seek medical advice.

Storage and use requirements

Aphthase α needs to be stored refrigerated at 2-8°C, avoiding freezing or direct sunlight. It needs to be placed at room temperature for no more than 3 hours before injection to ensure drug stability.

The correct use of aftase alfa is crucial to the therapeutic effect. Patients should undergo injections under the guidance of professional medical personnel and have regular follow-up visits to evaluate the efficacy.