阿福他酶α多少钱一盒?在哪里购买?

Afotalase α is an enzyme replacement therapy drug for hypophosphatasia (HPP). It is developed by Ruisong Pharmaceuticals in the United States and its trade name is Strensiq. This drug has not been officially approved for marketing in the country, and patients need to purchase it through overseas channels or special channels. The prices of different specifications of aftase alpha vary greatly. The price of 18mg/0.45mL/box is about US$13,210, while the price of 80mg/0.8mL/box is suitable for patients with larger body weight. The pharmacokinetics of afotalase α show that it is absorbed through subcutaneous injection and has a long half-life. The dosage needs to be adjusted under the guidance of a doctor.

How much does a box of aftase α cost?

The price varies depending on the specifications. Patients need to choose the appropriate dosage according to their own treatment needs. The drug has not yet been launched in the country, and price information mainly comes from overseas markets.

Price of 18mg/0.45mL/box

The price of 18mg/0.45mL/box of aftase alfa is approximately US$13,210, which is suitable for adult standard dose treatment. Usually 2-3 boxes are required per month, and long-term treatment costs are higher.

Price of other specifications

Afotalase α is also available in 28mg/0.7mL, 40mg/mL and 80mg/0.8mL. 80mg/0.8mL is suitable for patients with larger body weight, but is prohibited for patients weighing less than 40kg.

Factors affecting price

The high price of aftase alpha is related to its research and development costs, market positioning of rare disease drugs and the fact that it has not yet been approved in China. Some patients can reduce their financial burden through health insurance or assistance programs.

The price of aftase α is relatively high, and patients need to choose an appropriate purchase method based on their own financial situation and treatment needs.

Where to buy aftase α

Since aftase α has not yet been officially launched in China, patients need to obtain it through special channels. When purchasing, you need to pay attention to the reliability of the source of the medicine and avoid fake and shoddy products.

Purchase at regular overseas pharmacies

Patients can purchase it at regular hospitals or pharmacies in countries such as the United States, Japan or Europe where it has been marketed, and a doctor's prescription is required. This method has a reliable source of medicines, but international travel or mailing costs are incurred.

Medical service institutions

Some qualified international medical service institutions can provide aftase α purchase services. Before purchasing the drug, you need to verify the platform qualifications to ensure the authenticity of the drug.

Participate in domestic clinical trials

Some domestic medical institutions are conducting clinical trials of aftase alpha. Eligible patients can apply to participate and receive free drug treatment. This method needs to meet strict admissions criteria.

When purchasing aphthase α, you need to carefully choose formal channels and use it under the guidance of a doctor.

Pharmacokinetics of aftase α

The pharmacokinetic properties of aftase α determine its administration method and dose adjustment strategy, which has important guiding significance for clinical treatment.

Absorption and Distribution

Afotalase α is administered through subcutaneous injection. The absorption rate is slow but stable. The drug is mainly distributed in tissues such as bones and liver, where it plays an enzyme replacement role.

Metabolism and Excretion

Afotalase α is metabolized by proteolysis in the body and has a long half-life of about 5-7 days. Metabolites are mainly excreted through the kidneys.

Dose adjustment factors

The dose of aftase alfa needs to be adjusted according to the patient's weight, age and renal function. Pediatric patients need to accurately calculate the dosage, and those with renal insufficiency need to reduce the dosage.

Understanding the pharmacokinetics of afotalase α can help optimize treatment options, improve clinical efficacy and reduce adverse reactions.