Can I still take expired Ivonib/Tosovo? Is the risk high?

Ivosidenib/Tosovo（Ivosidenib) is an oral small molecule inhibitor targeting IDH1 gene mutation. It is mainly used for acute myeloid leukemia（AM Precision treatment of malignant hematological tumors such as L), cholangiocarcinoma (CCA), myelodysplastic syndrome (MDS), etc. It inhibits the activity ofIDH1 mutant protein, blocks the accumulation of abnormal metabolite 2-hydroxyglutarate, helps restore normal hematopoietic function, and thereby improves the clinical manifestations of patients. Since this drug is a targeted anti-cancer drug, its efficacy depends on the stability of the active ingredients. Therefore, whether expired drugs can still be taken is a concern of many patients and their families.

The expiry date on drug packaging is not randomly marked, but is the result of pharmaceutical companies' rigorous stability tests and repeated verification under certain temperature, humidity and light conditions. After the expiration date, the active ingredients of ivonib may gradually decompose, resulting in a decrease in efficacy. For patients with acute myeloid leukemia, the stability of drug concentration and efficacy is directly related to whether the disease can be controlled. Therefore, if the drug fails due to expiration, the cancer cells may not be inhibited, which may lead to accelerated progression of the disease.

In addition to reduced efficacy, expired ivosidenib may also pose potential safety hazards. When drugs are stored for too long or under improper storage conditions, degradation products may occur, and it is unpredictable whether these products will cause toxic side effects. For cancer patients whose liver and kidney functions are already susceptible to damage, this risk requires special vigilance. Once drug-induced liver injury or drug-induced adverse reactions occur, it may have a serious impact on the treatment plan.

Therefore, the medical community generally does not recommend continuing to take expired ivonib. If the patient finds that the medicine has expired, he should stop using it immediately and replace it with a new medicine under the guidance of a doctor. At the same time, proper storage of medications is equally important. Avosidenib should be placed in the original packaging and protected from direct sunlight, high temperature and humid environment to ensure that its efficacy is stable until the expiration date.

Reference: https://www.tibsovo.com/