Is the dosage of Deucravacitinib tablets one tablet per month?

A common misunderstanding about the usage and dosage of Deucravacitinib is that it is a long-acting preparation that means "one tablet a month". This is not actually the case. According to the standard dosage regimen recommended by the original drug manufacturer, the conventional dosage of deuterated colexitinib for the treatment of plaque psoriasis is 6 mg each time, once a day, orally. It is recommended to take the drug at a fixed time every day to maintain a stable drug concentration in the body and achieve a sustained anti-inflammatory effect.

The administration method is a daily maintenance oral treatment and does not have long-acting sustained-release characteristics. The tablet dosage form is designed to be released immediately and is quickly absorbed by the intestines and exerts its medicinal effect after taking it. Therefore, it is necessary to take the medicine on time every day to maintain the continuity of the medicinal effect. This is also different from some long-acting injectable biological agents such as IL-17 or IL-23 monoclonal antibodies, which can be injected every few weeks, while the treatment logic of deuterated colexitinib is based on continuous oral administration.

Although once-daily oral dosing may appear somewhat frequent to patients, the non-invasive delivery method of deuterated colexitinib is more conducive to long-term use and improves patient compliance compared with injection therapy. Especially among people who are afraid of injections, have unconditional long-term injections, or need to go out frequently, the convenience of oral medications is irreplaceable.

In actual use, it is recommended that patients take it regularly every day according to the doctor's prescription, such as after breakfast or at a fixed time before going to bed. It does not need to be accompanied by food, but if the patient has a sensitive gastrointestinal tract, it can also be taken with food to increase tolerance. In addition, do not change the dosage or take medication intermittently, especially when the psoriasis condition is not yet stable. Irregular use may lead to recurrence of symptoms or poor efficacy of the medication.

For some patients who wish to reduce the frequency of medication, deuterated coxitinib is not a long-acting monthly preparation. Its pharmacokinetic properties determine that it needs to be taken daily to maintain an effective anti-inflammatory response.

Reference materials:https://go.drugbank.com/drugs/DB16650