How to store and preserve Enactuzumab

Elranatamab is an innovative immunotherapy drug mainly used to treat relapsed or refractory multiple myeloma. The drug is a bispecific B cell maturation antigen (BCMA)-directed CD3 T cell engager that can activate T cells of the immune system through dual mechanisms, thereby effectively recognizing and attacking myeloma cells.

Before using eractuzumab, it is important to understand its proper storage and preservation methods to ensure the potency and safety of the drug. Eractuzumab injection (brand nameELREXFIO) is a sterile, preservative-free liquid solution with a slightly opalescent to colorless or light brown appearance. This medicine is available in single-dose vials, each containing 44 mg/1.1 ml or 76 mg/1.9 ml.

According to official recommendations, ernetuzumab should be stored in a refrigerated environment of 2°C to 8°C (i.e. 36°F to 46°F) to prevent the drug from reducing its efficacy due to temperature changes. Special attention should be paid to avoiding exposure to light when the drug is stored, as light may have an adverse effect on the stability of the drug. Therefore, enantuzumab should be kept in its original packaging and placed in a carton to prevent exposure to external light sources.

Medications should be kept refrigerated until use and should not be frozen or stored frozen. The bottles of medicines and the liquid in the packaging should not be shaken or violently vibrated, as this may affect the physical properties of the medicines and may even lead to reduced efficacy or the occurrence of adverse reactions. After the medicine is taken out of the refrigerator, it should be thawed naturally at room temperature without heating or accelerating the thawing process.

In short, the storage and preservation method of eractuzumab is very critical, and it must be stored strictly in accordance with the refrigeration requirements of 2°C to 8°C to ensure the stability and efficacy of the drug. Patients or health care facilities should follow proper storage instructions when using this medicine to ensure that the medicine is in optimal condition.

Reference materials:https://www.drugs.com/mtm/elranatamab.html