How many pills of Dasatinib should be taken a day for best results?

Dasatinib is an oral tyrosine kinase inhibitor mainly used to treat chronic myelogenous leukemia (CML) and Philadelphiachromosome-positive acute lymphoblastic leukemia (Ph+ ALL). For CMLpatients in the chronic phase, the recommended standard dose is 100mg once daily; for accelerated or blast phase CML and Ph+ For ALLpatients, the recommended dose is 140mg once a day. Common strengths of tablets are 20mg, 50mg, 70mg , 100mg, 140mg, etc. The specific dosage should be selected according to the total dose recommended by the doctor.

Research shows that dasatinib can maintain sufficient blood concentration in the body with once-daily administration and achieve sustained inhibition of BCR-ABL and other targets. Compared with the multiple-daily divided administration method used in the early days, once-daily administration not only facilitates patients to adhere to treatment, but also reduces the occurrence of side effects such as gastrointestinal discomfort and improves patient compliance. Therefore, as long as you take it according to the total dose, there is no need to divide it into multiple doses. Just take 1~2 tablets once a day (the specific number is determined by the specifications of the tablets).

Some patients may want to increase or decrease the dose of the drug on their own during the course of taking the drug due to adverse reactions, efficacy evaluation, or comorbidities with other diseases. This is not advisable. Dasatinib has dose-dependent side effects, such as bone marrow suppression, pleural effusion, etc. Randomly increasing the dose may increase the risk of toxic side effects, while reducing the dose may lead to drug resistance or reduced efficacy. Only when the doctor assesses that the patient's condition is stable and the response is good, the dosage may be considered to be adjusted, such as reducing 100 mg to 80 mg or 50 mg for maintenance treatment.

The common specifications of dasatinib are 100mg or 140mg, and usually only 1 pills are taken a day to meet treatment needs. If you are using 20mg or 50mgFor tablets of different specifications, the total dose needs to be converted into the number of pills per day. For example, if you need to take 100mg, you can choose 2 tablets 50mg or 5 tablets 20mg. You must strictly follow the doctor's advice. It is recommended that patients take it at a fixed time every day, and pay attention to the guidance of taking it on an empty stomach or with food (generally it can be taken with food or on an empty stomach without significant impact) to ensure stable efficacy.

Reference materials:https://www.drugs.com/