How much does a complete course of Zenocutuzumab treatment cost?

Zenocutuzumab is a bispecific monoclonal antibody targeting HER2 and HER3. It is mainly used to treat solid tumors carrying NRG1 gene fusion, such as non-small cell lung cancer and pancreatic cancer. This type of gene mutation is relatively rare, and patients often have limited response to traditional treatments. Therefore, zetolizumab is regarded as a new option for precise targeted therapy. The frequency of use is generally intravenous infusion once every two weeks, and the specific course of treatment depends on the patient's response to treatment and may last for several months or even more than a year.

Judging from the current public price, zetolizumab has not yet been launched in mainland China, and its market version mainly comes from the United States. Taking the US market price as an example, the cost of each 750mg infusion is approximately 2.3 US dollars, which is approximately 16 yuan in RMB. If the patient uses it once every two weeks, he will need about 26 infusions a year, and the annual treatment cost of a single drug is about 4.2 million yuan, excluding other expenses such as infusions, tests, and hospitalization.

If half a year is calculated as a medium course of treatment, the drug expenditure is approximately 2.10 yuan. Depending on the disease progression and treatment response, the duration of treatment may be shorter or longer for different patients, which will directly affect the total cost. Since this drug has not yet been included in the scope of medical insurance, and there are no generic substitutes, all treatment costs must be borne by the patients themselves, which is a heavy financial burden.

Overall, zetolizumab, as an innovative antibody drug targeting specific rare mutations, does bring new treatment hope to some patients with advanced tumors. However, due to its extremely high price and lack of medical insurance support, it is currently not suitable for most ordinary patients. It is recommended that patients should fully consult professional doctors before considering medication, evaluate their own financial conditions, pay attention to whether there are pharmaceutical company assistance projects or clinical trial opportunities, and seek possible cost reduction support.

Reference materials:https://www.drugs.com/