What drugs or foods should I avoid while using Aucatzyl?

Aucatzyl (Aucatzyl), as a type of CAR-T cellular immunotherapy, is sensitive to the interaction between drugs and food during the treatment process. Patients need to pay special attention to avoid using or ingesting it at the same time with certain drugs and foods to reduce the risk of adverse reactions and ensure efficacy. First of all, patients should avoid using immunosuppressive drugs, such as glucocorticoids and high-dose immunosuppressive drugs (cyclosporine, tacrolimus, etc.) while receiving Aucatzyl treatment. These drugs may inhibit the activity of CAR-T cells and reduce the therapeutic effect. Unless they are used short-term to control severe side effects, they should be used under the strict guidance of a doctor.

Patients should avoid concurrent use with drugs that may affect hepatic metabolism. Although Aucatzyl itself is a cell therapy, the lymphatic depletion program and complication management may involve a variety of chemotherapy drugs and supportive drugs, such as cyclophosphamide, fludarabine, antipyretic and analgesics, etc. If these drugs are combined with certain potent liver enzyme inducers or inhibitors (such as certain antifungal drugs, anti-epileptic drugs), they may affect metabolism, increase toxicity or reduce drug efficacy. You should inform your doctor in advance to adjust the plan.

In terms of food, patients should avoid foods that may cause abnormal immune system reactions or increase the risk of infection, such as insufficiently heated seafood, raw meat, raw eggs, and unpasteurized dairy products. At the same time, the intake of highly irritating foods, such as spicy, salty and fried foods, should be reduced to avoid increasing the burden on the gastrointestinal tract and affecting nutrient absorption and body recovery. Maintaining balanced nutrition and a light diet can help enhance physical strength and immune function.

Finally, patients should avoid taking unprescribed herbs, health products, or supplements during treatment. Some herbs may have complex interactions with the immune system, affecting CAR-T cell activity or exacerbating side effects. In addition, supplements such as vitamin E and large doses of antioxidants may also interfere with the therapeutic effect. Patients should truthfully inform their doctors about all medications and supplements they take to ensure safe and smooth treatment.

Reference materials:https://www.drugs.com/