Will fezonatant affect women's menstruation during use?

Fezolinetant is a selective neurokinin 3 (NK3) receptor antagonist, mainly used to relieve vasomotor symptoms in perimenopausal and postmenopausal women, such as hot flashes and night sweats. Because it does not act on estrogen receptors, but works by regulating the neuropeptide pathway of the thermoregulatory center in the hypothalamus of the brain, it does not directly interfere with the female endocrine system at the hormonal level like traditional hormone replacement therapy.

Judging from the existing clinical data, fezonatant has a small impact on the menstrual cycle, especially when used in women who are already menopausal or close to menopause, and is less likely to cause the resumption of bleeding or the return of menstruation. This is closely related to the fact that it does not have estrogen-like effects, unlike some hormone drugs that may stimulate the endometrium and induce irregular vaginal bleeding.

However, in some perimenopausal women who are not yet completely menopausal, individual hormone levels fluctuate greatly, and the period of taking nonazonitant may be intertwined with the original cycle disorder. A few patients may experience early menstruation, delayed menstruation, or mild bleeding. However, this is often not related to the direct effect of the drug, and is more commonly caused by endogenous hormone changes or other drug interference. If you have persistent menstrual abnormalities, it is recommended to seek medical treatment in time to rule out the possibility of other gynecological diseases.

In summary, as a non-hormonal drug, fezonatant usually does not significantly interfere with the menstrual cycle or cause abnormal bleeding, and is relatively safe to use in perimenopausal women. However, considering individual differences, if obvious menstrual disorders or abnormal symptoms occur while taking the medicine, you should still consult a doctor in time and conduct necessary evaluation.

Reference materials:https://www.drugs.com