Is Vorasidenib currently available in domestic hospitals?

Currently, Vorasidenib (Vorasidenib) has not been officially approved for marketing in mainland China, so it cannot be used directly in most domestic hospitals. This drug is a new targeted treatment drug for IDH1/IDH2mutated grade II glioma. The main channel currently available is the policy arrangement of "clinically urgently needed imported drugs" in the Hainan Boao Lecheng International Medical Tourism Pilot Zone.

In designated hospitals in Boao Lecheng, such as Southwest Hospital and Lecheng Hospital, voxanib has been put into use as a "clinically urgently needed imported drug" and is suitable for patients with diffuse gliomas carrying IDH1/2 mutations, which means that domestic patients can apply for this drug for treatment if they meet the conditions. In addition, many Chinese tertiary hospitals (such as Beijing Tiantan, Shanghai Huashan, and Shenzhen Second Hospital) are conducting bridging clinical trials for Chinese patients, and participants can use voxanib under the trial framework.

In terms of usage, vorsidenib is an oral IDH1/IDH2 dual-target inhibitor, suitable for patients with grade II glioma carrying IDH mutations after surgery. The dose is once a day40 mg, continue until disease progression or intolerance. Clinical data shows that the drug can significantly extend progression-free survival (PFS) from 11.1 months to 27.7 months.

In summary, although voroxiranib has not yet been routinely marketed in China, domestic patients can still obtain access to it through two channels: one is to receive "clinically urgently needed imported drugs" in Boao Lecheng; the other is to participate in the ongoing bridging clinical trials in tertiary hospitals in big cities. These channels have brought practical treatment options to domestic IDHmutant glioma patients. As clinical trials progress and regulatory approvals accelerate, the drug is expected to be used in more hospitals and a wider range of patient groups in the future.

Reference materials:https://www.drugs.com