Calculation of the dosage of one box of fenelidone and the number of days of taking it

Finerenone is usually provided in the form of oral tablets . Common specifications are 10mg*14 tablets and 20mg*7 tablets. The starting and maintenance doses of fenelidone vary based on the patient's renal function (eGFR). Proper dosage helps achieve optimal therapeutic results while reducing the occurrence of side effects.

For patients The generally recommended starting dose is 20 mg once daily for patients with eGFR ≥ 60mL/min/1.73m². This dose is suitable for patients with good kidney function and can help regulate mineralocorticoid levels, reduce proteinuria, and effectively improve kidney function. Based on the patient's treatment response, the doctor may later adjust the dose to 20 mg once daily as the target maintenance dose.

For patients eGFR≥25 to<60mL/min/1.73m², the recommended starting dose is 10mg once daily. This dose is suitable for patients with poor renal function but not yet renal failure. The dose can be gradually adjusted according to the patient's tolerance of the drug, with the target maintenance dose usually being 20 mg once daily, but this needs to be done under the supervision of a physician.

For patients Fenelidone is not recommended for patients with eGFR <25mL/min/1.73m². This is because in patients with severe renal impairment, drug metabolism and clearance may be affected, increasing the risk of drug side effects, especially potentially fatal side effects such as hyperkalemia.

Regarding the calculation of the number of days of taking, if you follow the common specifications of 10mg*14 tablets or 20mg*7 tablets , patients can calculate the number of days of taking it based on their daily dosage. For example:

10 mg strength (14 tablets): If a patient starts at 10 mg once daily, one box of tablets will last 14 days. 20 mg strength (7 tablets): If a patient starts at 20 mg once daily, one box of tablets will last for 7 days. If the patient's target maintenance dose is 20 mg once a day, then take 20 mg every day, and a box of 20 mg*7 tablets is enough for 7 days. For patients who require long-term treatment, multiple boxes of the medication are often prescribed to ensure there are no interruptions during treatment.

Reference materials:https://www.kerendia.com/