Is guanfacine available in extended-release tablet form?

Guanfacine is a drug mainly used to treat ADHD and certain types of hypertension. Its sustained-release tablet form is particularly widely used in clinical applications. Specifically, guanfacine for ADHD is usually available in extended-release tablet form, under the brand name Intuniv. This dosage form is designed to achieve smooth release of the drug's effect over 24 hours, thereby helping patients maintain stable attention levels and improve behavioral control while minimizing the occurrence of fluctuating side effects. The biggest advantage of the sustained-release dosage form is that it avoids the fluctuation in drug efficacy that may be caused by traditional short-acting preparations, especially in children and adolescents, and improves concentration in daily activities and medication compliance.

Guanfacine extended-release tablets are available in a variety of specifications: 1mg, 2mg, 3mg and 4mg, which facilitates doctors to adjust the dose individually based on the patient's weight, age and tolerance. Patients should follow the principle of "swallowing the tablet whole" when using it and avoid breaking or chewing the tablet to ensure that the sustained-release mechanism fully functions. If broken and taken, a large amount of the drug may be released in a short period of time, causing adverse reactions such as drowsiness, hypotension, or abnormal heart rate. Sustained-release tablets should be taken once a day. It is recommended to take the drug at a fixed time every day to maintain stable blood concentration.

Guanfacine extended-release tablets, as a non-stimulant treatment for ADHD, have been approved by the FDA as monotherapy for children aged 6 to 17 years old. They are especially suitable for patients who are intolerant to central stimulant drugs (such as methylphenidate, amphetamines, etc.) or have side effects. In addition, it also shows unique advantages for ADHD patients with anxiety, mood swings, or sleep disorders. By acting on α2A-adrenergic receptors in the brain's prefrontal cortex, it can enhance executive functions, extend attention span, and help regulate emotional impulses.

Reference materials:https://go.drugbank.com/drugs/DB01018