Does Seleniso need to be kept refrigerated? What are the relevant requirements?

Selinexor is an oral selective inhibitor of nuclear export used to treat multiple myeloma and other malignant tumors. It belongs to the SINE (Selective Inhibitor of Nuclear Export) class of drugs. This drug inhibits the activity of CRM1/XPO1 protein, interferes with the excretion of tumor suppressor proteins by tumor cells, and induces cell apoptosis. During clinical use, the storage and preservation conditions of drugs are key factors to ensure efficacy and safety.

According to the information provided by the U.S. FDA and the original drug manufacturer, Selinisol is supplied in tablet form, usually in 20 mg or 40 mg specifications. This medicine does not need to be refrigerated, that is, it does not need to be stored in a refrigerator environment between 2°C and 8°C. It should be stored at room temperature, 20°C to 25°C (68°F to 77°F), with permitted short-term temperature fluctuations in the range of 15°C to 30°C (59°F to 86°F). During the storage of pharmaceuticals, direct sunlight and high temperature and humid environments should be avoided, as excessive temperature or humidity may affect the stability of its active ingredients.

In addition, it is recommended that medicines should be sealed and stored in their original packaging to avoid being exposed to the air for too long after opening to prevent tablets from deteriorating due to moisture absorption or oxidation. If the air humidity in the home environment is high, it is recommended to use a desiccant or store it in a closed medicine box and place it out of the reach of children to avoid accidental ingestion. According to the drug management practices of a hospital or pharmacy, selinexol is a prescription drug and has potentially serious side effects. It must be stored strictly in accordance with label instructions.

For individual patients, avoid placing it in areas with obvious temperature fluctuations such as bathrooms, windows, or kitchens. If the tablets appear discolored, deformed, have an abnormal odor, etc., stop using them immediately and contact your pharmacist to confirm the effectiveness of the medicine. In addition, it is not recommended to dispose of remaining medicines through ordinary garbage. You should consult a pharmacist or go through a drug recycling agency for harmless disposal.

Reference materials:https://www.selincro.com/